MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in
biological processes spanning from early developmental stages to the intricate process of …

Gene-gene interactions are crucial to the control of sub-cellular processes but our
understanding of their stochastic dynamics is hindered by the lack of simulation methods …

Gene expression in mammalian cells is highly variable and episodic, resulting in a series of
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …

The amazing complexity of gene regulatory circuits, and biological systems in general,
makes mathematical modeling an essential tool to frame and develop our understanding of …

Understanding self-organized pattern formation is fundamental to biology. In 1952, Alan
Turing proposed a pattern-enabling mechanism in reaction-diffusion systems containing …

Epithelial–mesenchymal transition (EMT) and its reverse mesenchymal–epithelial transition
(MET) are critical during embryonic development, wound healing and cancer metastasis …

Ultrasensitive transcriptional switches enable sharp transitions between transcriptional on
and off states and are essential for cells to respond to environmental cues with high fidelity …

Simple Summary Small cell lung cancer (SCLC) is an aggressive cancer that is difficult to
treat. There are at least five subtypes of SCLC cells, defined by gene expression signatures …

Studies of quantitative systems and synthetic biology have extensively utilized models to
interpret data, make predictions, and guide experimental designs. However, models often …

Phenotypic heterogeneity along the epithelial-mesenchymal (EM) axis contributes to cancer
metastasis and drug resistance. Recent experimental efforts have collated detailed time …