Galactose is an essential carbohydrate for cellular metabolism, as it contributes to energy
production and storage in several human tissues while also being a precursor for …

Carbohydrate chains are the most abundant and diverse of nature's biopolymers and
represent one of the four fundamental macromolecular building blocks of life together with …

Increased blood levels of low-density lipoprotein cholesterol (LDL-C) and fibrinogen are
independent risk factors for cardiovascular disease. We identified associations between an …

Glycosyltransferases are nature's versatile tools to tailor the functionalities of proteins,
carbohydrates, lipids, and small molecules by transferring sugars. Prominent substrates are …

β-1, 4-Galactosyltransferase 1 (B4GALT1) and ST6 β-galactoside α-2, 6-sialyltransferase 1
(ST6GAL1) catalyze the successive addition of terminal β-1, 4–linked galactose and α-2, 6 …

Uridine diphosphate-dependent glycosyltransferases (UGTs) mediate the glycosylation of
plant metabolites, thereby altering their physicochemical properties and bioactivities. Plants …

Background ZIP8, encoded by SLC39A8, is a membrane transporter that facilitates the
cellular uptake of divalent biometals including zinc (Zn), manganese (Mn), and iron (Fe). The …

N-glycosylation is an important posttranslational modification affecting the properties and
quality of therapeutic proteins. Glycoengineering in yeast aims to produce proteins carrying …

Abstract β1, 4-galactosyltransferase 4 (B4GalT4) is one of seven B4GalTs that belong to
CAZy glycosyltransferase family 7 and transfer galactose to growing sugar moieties of …

The β-1, 4 galactosylation catalyzed by β-1, 4 galactosyltransferases (β4Gal-Ts) is not only
closely associated with diverse physiological and pathological processes in humans but …