Mesenchymal stem/stromal cell-based therapy: mechanism, systemic safety and biodistribution for precision clinical applications

WZ Zhuang, YH Lin, LJ Su, MS Wu, HY Jeng… - Journal of biomedical …, 2021 - Springer
Mesenchymal stem/stromal cells (MSCs) are a promising resource for cell-based therapy
because of their high immunomodulation ability, tropism towards inflamed and injured …

Therapeutic potential of mesenchymal stem cells for cancer therapy

A Hmadcha, A Martin-Montalvo, BR Gauthier… - … in bioengineering and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are among the most frequently used cell type for
regenerative medicine. A large number of studies have shown the beneficial effects of MSC …

Human umbilical cord mesenchymal stem cells: a new era for stem cell therapy

DC Ding, YH Chang, WC Shyu, SZ Lin - Cell transplantation, 2015 - journals.sagepub.com
The human umbilical cord is a promising source of mesenchymal stem cells (HUCMSCs).
Unlike bone marrow stem cells, HUCMSCs have a painless collection procedure and faster …

Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications

DW Kim, M Staples, K Shinozuka, P Pantcheva… - International journal of …, 2013 - mdpi.com
Wharton's jelly (WJ) is a gelatinous tissue within the umbilical cord that contains
myofibroblast-like stromal cells. A unique cell population of WJ that has been suggested as …

Human Wharton's jelly stem cells have unique transcriptome profiles compared to human embryonic stem cells and other mesenchymal stem cells

CY Fong, LL Chak, A Biswas, JH Tan… - Stem Cell Reviews and …, 2011 - Springer
The human umbilical cord that originates from the embryo is an extra-embryonic membrane
and the Wharton's jelly within it is a rich source of stem cells (hWJSCs). It is not definitely …

[HTML][HTML] Recent advances in regenerative medicine strategies for cancer treatment

V Mansouri, N Beheshtizadeh, M Gharibshahian… - Biomedicine & …, 2021 - Elsevier
Cancer stands as one of the most leading causes of death worldwide, while one of the most
significant challenges in treating it is revealing novel alternatives to predict, diagnose, and …

The therapeutic potential, challenges and future clinical directions of stem cells from the Wharton's jelly of the human umbilical cord

A Bongso, CY Fong - Stem Cell Reviews and Reports, 2013 - Springer
Mesenchymal stem cells (MSCs) from bone marrow, adult organs and fetuses face the
disadvantages of invasive isolation, limited cell numbers and ethical constraints while …

Microvesicles Derived from Human Umbilical Cord Wharton's Jelly Mesenchymal Stem Cells Attenuate Bladder Tumor Cell Growth In Vitro and In Vivo

S Wu, GQ Ju, T Du, YJ Zhu, GH Liu - PloS one, 2013 - journals.plos.org
Several studies suggest that mesenchymal stem cells (MSCs) possess antitumor properties;
however, the exact mechanisms remain unclear. Recently, microvesicles (MVs) are …

Wharton's jelly derived mesenchymal stem cells: future of regenerative medicine? Recent findings and clinical significance

I Kalaszczynska, K Ferdyn - BioMed research international, 2015 - Wiley Online Library
Around 5 million annual births in EU and 131 million worldwide give a unique opportunity to
collect lifesaving Wharton's jelly derived mesenchymal stem cells (WJ‐MSC). Evidences that …

[HTML][HTML] Biodistribution of gadolinium-and near infrared-labeled human umbilical cord mesenchymal stromal cell-derived exosomes in tumor bearing mice

J Abello, TDT Nguyen, R Marasini, S Aryal… - Theranostics, 2019 - ncbi.nlm.nih.gov
We speculate that exosomes derived from human umbilical cord mesenchymal stromal cells
(HUC-MSCs) will accumulate within tumors and have the potential for both tumor location or …