Interplay between gene expression noise and regulatory network architecture

G Chalancon, CNJ Ravarani, S Balaji… - Trends in genetics, 2012 - cell.com
Complex regulatory networks orchestrate most cellular processes in biological systems.
Genes in such networks are subject to expression noise, resulting in isogenic cell …

Transcriptional regulation in archaea: from individual genes to global regulatory networks

M Martinez-Pastor, PD Tonner… - Annual review of …, 2017 - annualreviews.org
Archaea are major contributors to biogeochemical cycles, possess unique metabolic
capabilities, and resist extreme stress. To regulate the expression of genes encoding these …

Construction and analysis of an integrated regulatory network derived from high-throughput sequencing data

C Cheng, KK Yan, W Hwang, J Qian… - PLoS computational …, 2011 - journals.plos.org
We present a network framework for analyzing multi-level regulation in higher eukaryotes
based on systematic integration of various high-throughput datasets. The network, namely …

[HTML][HTML] Phosphorylation of estrogen receptor α at serine 118 is correlated with breast cancer resistance to tamoxifen

M Chen, YK Cui, WH Huang, K Man… - Oncology …, 2013 - spandidos-publications.com
The aim of the present study was to explore the correlation between estrogen receptor α
(ERα) phosphorylation at serines 118 and 167 and the responsiveness of patients with …

[HTML][HTML] Genome-wide analysis of alternative splicing events in Hordeum vulgare: Highlighting retention of intron-based splicing and its possible function through …

B Panahi, SA Mohammadi, RE Khaksefidi… - FEBS letters, 2015 - Elsevier
In this study, using homology mapping of assembled expressed sequence tags against the
genomic data, we identified alternative splicing events in barley. Results demonstrated that …

Two transcription factors are necessary for iron homeostasis in a salt-dwelling archaeon

AK Schmid, M Pan, K Sharma… - Nucleic acids research, 2011 - academic.oup.com
Because iron toxicity and deficiency are equally life threatening, maintaining intracellular
iron levels within a narrow optimal range is critical for nearly all known organisms. However …

Control of asymmetric Hopfield networks and application to cancer attractors

A Szedlak, G Paternostro, C Piermarocchi - PloS one, 2014 - journals.plos.org
The asymmetric Hopfield model is used to simulate signaling dynamics in gene regulatory
networks. The model allows for a direct mapping of a gene expression pattern into attractor …

Genome-wide patterns of promoter sharing and co-expression in bovine skeletal muscle

Q Gu, SH Nagaraj, NJ Hudson, BP Dalrymple… - BMC genomics, 2011 - Springer
Background Gene regulation by transcription factors (TF) is species, tissue and time specific.
To better understand how the genetic code controls gene expression in bovine muscle we …

A systems biology model of the regulatory network in Populusleaves reveals interacting regulators and conserved regulation

NR Street, S Jansson, TR Hvidsten - BMC plant biology, 2011 - Springer
Background Green plant leaves have always fascinated biologists as hosts for
photosynthesis and providers of basic energy to many food webs. Today, comprehensive …

Structure, evolution and dynamics of transcriptional regulatory networks

MM Babu - Biochemical Society Transactions, 2010 - portlandpress.com
The availability of entire genome sequences and the wealth of literature on gene regulation
have enabled researchers to model an organism's transcriptional regulation system in the …