Recent studies indicate that a higher body mass index (BMI) might correlate with improved
responses to melanoma treatment, especially with immune checkpoint inhibitors (ICIs) …

Growing interest has emerged in the role of sex, as a biological variable that influence the
immunopathogenesis of melanoma. Female patients exhibit significantly better disease …

Background Stimulator of Interferon Genes (STING) is a dsDNA sensor that triggers type I
inflammatory responses. Recent data from our group and others support the therapeutic …

Background There is paucity of data on how gender impacts melanoma prognosis in
pediatric and adolescent patients. Objectives This study explores gender differences in …

Objective The objective of this study was to identify the risk factors that influence metastasis
and prognosis in patients with nodular melanoma (NM), as well as to develop and validate a …

The human leukocyte antigene E (HLA-E) is associated with tumorigenesis in various
cancers. Immunoncology along with sex-specific aspects in cancer therapy are now in …

Background Although the recent drop in melanoma mortality has been attributed to the
introduction of newer therapies, the impact of ongoing public efforts remains unknown …

Successful infiltration of pro-inflammatory immune cells into the tumor can promote an anti-
tumor microenvironment that leads to tumor growth control and regression. However, the …

Orale Plattenepithelkarzinome (OSCC) gehören zu den häufigsten Tumorentitäten weltweit.
Trotz Bemühungen in der Forschung und der Therapie ist die Prognose weiterhin schlecht …

Background: There are multiple sex disparities across numerous cancers affecting
incidence, survival, and treatment response. In cutaneous melanoma (CM), men have a …