A Novel Immunomodulatory Hemocyanin from the Limpet Fissurella latimarginata Promotes Potent Anti-Tumor Activity in Melanoma

S Arancibia, C Espinoza, F Salazar, M Del Campo… - PloS one, 2014 - journals.plos.org
Hemocyanins, the huge oxygen-transporting glycoproteins of some mollusks, are used as
immunomodulatory proteins with proven anti-cancer properties. The biodiversity of …

[HTML][HTML] Hemocyanins stimulate innate immunity by inducing different temporal patterns of proinflammatory cytokine expression in macrophages

TY Zhong, S Arancibia, R Born, R Tampe… - The Journal of …, 2016 - journals.aai.org
Hemocyanins induce a potent Th1-dominant immune response with beneficial clinical
outcomes when used as a carrier/adjuvant in vaccines and nonspecific immunostimulant in …

[HTML][HTML] A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth

MA Gleisner, C Pereda, A Tittarelli… - … for ImmunoTherapy of …, 2020 - ncbi.nlm.nih.gov
Background Immune checkpoint blocker (ICB) therapy has shown survival benefits for some
patients with cancer. Nevertheless, many individuals remain refractory or acquire resistance …

Immunotherapeutic potential of mollusk hemocyanins in combination with human vaccine adjuvants in murine models of oral cancer

JJ Mora Román, M Del Campo, J Villar… - Journal of …, 2019 - Wiley Online Library
Mollusk hemocyanins have been used for decades in immunological and clinical
applications as natural, nontoxic, nonpathogenic, and nonspecific immunostimulants for the …

Hemocyanin of the molluscan Concholepas concholepas exhibits an unusual heterodecameric array of subunits

P De Ioannes, B Moltedo, H Oliva, R Pacheco… - Journal of Biological …, 2004 - ASBMB
We describe here the structure of the hemocyanin from the Chilean gastropod Concholepas
concholepas (CCH), emphasizing some attributes that make it interesting among molluscan …

Enhanced structural stability of Concholepas hemocyanin increases its immunogenicity and maintains its non‐specific immunostimulatory effects

S Arancibia, MD Campo, E Nova… - European journal of …, 2012 - Wiley Online Library
Hemocyanins, which boost the immune system of mammals, have been used as carrier‐
adjuvants to promote Ab production against haptens and peptides, as immunostimulants …

Immunodominant role of CCHA subunit of Concholepas hemocyanin is associated with unique biochemical properties

MI Becker, A Fuentes, M Del Campo… - International …, 2009 - Elsevier
Hemocyanin, the oxygen transporter metallo-glycoprotein from mollusks, shows strong
relationship between its notable structural features and intrinsic immunomodulatory effects …

Molluskan hemocyanins activate the classical pathway of the human complement system through natural antibodies

J Pizarro-Bauerle, I Maldonado… - Frontiers in …, 2017 - frontiersin.org
Molluskan hemocyanins are enormous oxygen-carrier glycoproteins that show remarkable
immunostimulatory properties when inoculated in mammals, such as the generation of high …

Antitumor activity and carrier properties of novel hemocyanins coupled to a mimotope of GD2 ganglioside

M Palacios, R Tampe, M Del Campo, TY Zhong… - European Journal of …, 2018 - Elsevier
Conjugation to carrier proteins is a way to improve the immunogenicity of peptides. Such is
the case for peptides mimicking carbohydrate tumor-associated antigens in cancer vaccine …

Hemocyanins in the immunotherapy of superficial bladder cancer

S Arancibia, F Salazar, MI Becker - Bladder Cancer–From Basic …, 2012 - books.google.com
Chemo-and immunotherapeutic approaches have been used to prevent recurrence of
transitional cell carcinoma (TCC), the most common type of superficial bladder cancer …