[HTML][HTML] Mitochondrial alterations in fatty liver diseases

B Fromenty, M Roden - Journal of hepatology, 2023 - Elsevier
Fatty liver diseases can result from common metabolic diseases, as well as from xenobiotic
exposure and excessive alcohol use, all of which have been shown to exert toxic effects on …

Hepatoprotective effect of kaempferol: a review of the dietary sources, bioavailability, mechanisms of action, and safety

MY Alkandahri, BT Pamungkas… - Advances in …, 2023 - Wiley Online Library
The liver is the body's most critical organ that performs vital functions. Hepatic disorders can
affect the physiological and biochemical functions of the body. Hepatic disorder is a …

Structure and hepatoprotective activity of Usp10/NF-κB/Nrf2 pathway-related Morchella esculenta polysaccharide

S Teng, Y Zhang, X Jin, Y Zhu, L Li, X Huang… - Carbohydrate …, 2023 - Elsevier
The water-soluble Morchella esculenta polysaccharide 2 (MEP2) was purified and isolated
from an aqueous extract of the Morchella esculenta fruiting bodies. MEP2, having a …

USP14 governs CYP2E1 to promote nonalcoholic fatty liver disease through deubiquitination and stabilization of HSP90AA1

D Wei, X Tian, L Zhu, H Wang, C Sun - Cell Death & Disease, 2023 - nature.com
Nonalcoholic fatty liver disease (NAFLD) begins with excessive triglyceride accumulation in
the liver, and overly severe hepatic steatosis progresses to nonalcoholic steatohepatitis …

[HTML][HTML] Alcohol-induced liver injury in signalling pathways and curcumin's therapeutic potential

V Subramaniyan, NSA Lubau, N Mukerjee… - Toxicology Reports, 2023 - Elsevier
Confronting the profound public health concern of alcohol-induced liver damage calls for
inventive therapeutic measures. The social, economic, and clinical ramifications are …

[HTML][HTML] Research progress on rodent models and its mechanisms of liver injury

J Mao, L Tan, C Tian, W Wang, H Zhang, Z Zhu, Y Li - Life Sciences, 2024 - Elsevier
The liver is the most important organ for biological transformation in the body and is crucial
for maintaining the body's vital activities. Liver injury is a serious pathological condition that …

Graphene oxide-induced, reactive oxygen species-mediated mitochondrial dysfunctions and apoptosis: high-dose toxicity in normal cells

AA Imarah, MS Jabir, AH Abood, GM Sulaiman… - …, 2023 - Taylor & Francis
Aim: The cytotoxic effects of graphene oxide nanoparticles (GONPs) using MTT assays,
observance of apoptotic markers, and oxidative stress were outlined. Materials & methods …

Paeoniflorin protects hepatocytes from APAP-induced damage through launching autophagy via the MAPK/mTOR signaling pathway

X Deng, Y Li, Y Chen, Q Hu, W Zhang, L Chen… - Cellular & Molecular …, 2024 - Springer
Background Drug-induced liver injury (DILI) is gradually becoming a common global
problem that causes acute liver failure, especially in acute hepatic damage caused by …

Mitochondrial Dysfunction in Metabolic Dysfunction Fatty Liver Disease (MAFLD)

Y Zhao, Y Zhou, D Wang, Z Huang, X Xiao… - International Journal of …, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in
Western countries and has become the major cause of liver cirrhosis or hepatocellular …

Confined cascade metabolic reprogramming nanoreactor for targeted alcohol detoxification and alcoholic liver injury management

X Geng, X Du, W Wang, C Zhang, X Liu, Y Qu… - ACS …, 2023 - ACS Publications
Alcoholic liver injury (ALI) is the leading cause of serious liver disease, whereas current
treatments are mostly supportive and unable to metabolize alcohol directly. Here we report a …