The cAMP-dependent protein kinase (PKA) system represents a primary cell-signaling
pathway throughout systems and across species. PKA facilitates the actions of hormones …

Circadian rhythms that influence mammalian homeostasis and overall health have received
increasing interest over the past two decades. The molecular clock, which is present in …

Extracellular acidification occurs in inflamed tissue and the tumor microenvironment;
however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking …

Exercise is an effective non-pharmacological strategy for ameliorating nonalcoholic fatty
liver disease (NAFLD), but the underlying mechanism needs further investigation. Cysteine …

The distribution and function of sympathetic innervation in skeletal muscle have largely
remained elusive. Here we demonstrate that sympathetic neurons make close contact with …

In a mature (weight neutral) animal, an increase in muscle mass only occurs when the
muscle is loaded sufficiently to cause an increase in myofibrillar protein balance. A tight …

The brain has the ability to sense, coordinate, and respond to environmental changes
through biological processes involving activity-dependent gene expression. cAMP-response …

The composition and activity of the gut microbiota depend on the host genome, nutrition, and
life-style. Exercise and sodium butyrate (NaB) exert metabolic benefits in both mice and …

Reduction in daily activity leads to dramatic metabolic disorders, while regular aerobic
exercise training is effective for preventing this problem. The purpose of this study was to …

The molecular targets and mechanisms of propolis ameliorating metabolic syndrome are not
fully understood. Here, we report that Brazilian green propolis reduces fasting blood glucose …