Insulin plays a range of roles as an anabolic hormone in peripheral tissues. It regulates
glucose metabolism, stimulates glucose transport into cells and suppresses hepatic glucose …

Central nervous system (CNS) barriers predominantly mediate the immune-privileged status
of the brain, and are also important regulators of neuroimmune communication. It is …

Metabolic dysfunction is a well-established feature of Alzheimer's disease (AD), evidenced
by brain glucose hypometabolism that can be observed potentially decades prior to the …

Brain insulin signaling contributes to memory function and might be a viable target in the
prevention and treatment of memory impairments including Alzheimer's disease. This short …

Insulin performs unique functions within the CNS. Produced nearly exclusively by the
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …

Recent research suggests that increased adiposity is associated with poor cognitive
performance, independently of associated medical conditions. The evidence regarding this …

Background Few prospective studies have assessed diabetes mellitus as a risk factor for
incident Alzheimer disease (AD) and decline in cognitive function. Objective To evaluate the …

A growing body of evidence links type-2 diabetes (T2D) with dementia and
neurodegenerative diseases such as Alzheimer's disease (AD). AD is the most common …

Insulin has functions in the brain and dysregulation of these functions may contribute to the
expression of late-life neurodegenerative disease. We provide a brief summary of research …

Somatostatin (SST) is a well-known neuropeptide that is expressed throughout the brain. In
the cortex, SST is expressed in a subset of GABAergic neurons and is known as a protein …