Abstract Disclosed herein are Clustered Regularly Interspaced Short Palindromic Repeats
(CRISPR)/CRISPR-associated (Cas) 9-based system related compositions and methods of …

The invention provides for delivery, engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences. Provided …

The present invention provides novel isolated and purified polynucleotides and
polypeptides related to a novel ligand for glucocorticoid-induced TNF receptor (GITR). The …

5589.466 A 12/1996 Felgner et al. Cloning and characterization of the promoter region of a
5,593.972 A 1/1997 Weiner et al. gene encoding a 67-KDa glycoprotein, J Biol Chem …

Methods of prophylactic and therapeutic immunization of an individual against pathogen
infection, diseases associated with hyperproliferative cells and autoimmune diseases are …

US PATENT DOCUMENTS Lactobacillus bulgaricuS protoplasts by bacteriophage
4,784,952 A* 11/1988 Ludwig et al. DNA, Appl Environ Microbiol, 54 (12): 301.4–8. 5.264 …

Methods of introducing genetic material into cells of an individual and compositions and kits
for practicing the same are disclosed. The methods comprise the steps of contacting cells of …

(57) ABSTRACT (List continued on next page.) The invention provides a number of
Strategies for transfer FOREIGN PATENT DOCUMENTS ring and/or evolving gene (s) …

The invention provides a number of strategies for transferring and/or evolving gene (s)
associated with cellular DNA uptake so that they confer or enhance DNA-uptake capacity of …

The invention provides for delivery, engineering and optimization of systems, methods, and
compositions for manipulation of sequences and/or activities of target sequences especially …