cAMP-PKA/EPAC signaling and cancer: the interplay in tumor microenvironment
H Zhang, Y Liu, J Liu, J Chen, J Wang, H Hua… - Journal of Hematology & …, 2024 - Springer
Cancer is a complex disease resulting from abnormal cell growth that is induced by a
number of genetic and environmental factors. The tumor microenvironment (TME), which …
number of genetic and environmental factors. The tumor microenvironment (TME), which …
[HTML][HTML] ERBB3 targeting: a promising approach to overcoming cancer therapeutic resistance
Human epidermal growth factor receptor-3 (ERBB3) is a member of the ERBB receptor
tyrosine kinases (RTKs) and is expressed in many malignancies. Along with other ERBB …
tyrosine kinases (RTKs) and is expressed in many malignancies. Along with other ERBB …
Archetype tasks link intratumoral heterogeneity to plasticity and cancer hallmarks in small cell lung cancer
Small cell lung cancer (SCLC) tumors comprise heterogeneous mixtures of cell states,
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
categorized into neuroendocrine (NE) and non-neuroendocrine (non-NE) transcriptional …
Suppressing STAT3 activity protects the endothelial barrier from VEGF-mediated vascular permeability
Vascular permeability triggered by inflammation or ischemia promotes edema, exacerbates
disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) …
disease progression and impairs tissue recovery. Vascular endothelial growth factor (VEGF) …
The uprise of RNA biology in neuroendocrine neoplasms: altered splicing and RNA species unveil translational opportunities
R Blázquez-Encinas, MT Moreno-Montilla… - Reviews in Endocrine …, 2023 - Springer
Neuroendocrine neoplasms (NENs) comprise a highly heterogeneous group of tumors
arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal …
arising from the diffuse neuroendocrine system. NENs mainly originate in gastrointestinal …
Radiation dermatitis in the hairless mouse model mimics human radiation dermatitis
Over half of all people diagnosed with cancer receive radiation therapy. Moderate to severe
radiation dermatitis occurs in most human radiation patients, causing pain, aesthetic …
radiation dermatitis occurs in most human radiation patients, causing pain, aesthetic …
DARPP-32 promotes ERBB3-mediated resistance to molecular targeted therapy in EGFR-mutated lung adenocarcinoma
Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI)-refractory lung
adenocarcinoma (LUAD) progression is a major clinical problem. New approaches to …
adenocarcinoma (LUAD) progression is a major clinical problem. New approaches to …
ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation
Background Small cell lung cancer (SCLC) is the most aggressive form of lung cancer, and
new molecular insights are necessary for prognostic and therapeutic advances. Methods …
new molecular insights are necessary for prognostic and therapeutic advances. Methods …
[HTML][HTML] Quercetin inhibits truncated isoform of dopamine-and cAMP-regulated phosphoprotein as adjuvant treatment for Trastuzumab therapy resistance in HER2 …
HS Chang, TC Cheng, SH Tu, CH Wu, YC Liao… - Food Science and …, 2024 - Elsevier
Trastuzumab resistance is one of the causes of poor prognosis in patients with human
epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer (BC). The …
epidermal growth factor receptor 2 (HER2)-positive (HER2+) breast cancer (BC). The …
NDR1 activates CD47 transcription by increasing protein stability and nuclear location of ASCL1 to enhance cancer stem cell properties and evasion of phagocytosis …
LL Wang, XY Wan, TL Wang, CQ Liu, FM Zheng - Medical Oncology, 2022 - Springer
Small cell lung cancer (SCLC) is one of the most malignant types of lung cancer. Cancer
stem cell (CSC) and tumor immune evasion are critical for the development of SCLC. We …
stem cell (CSC) and tumor immune evasion are critical for the development of SCLC. We …