RUNX1 is a member of the core-binding factor family of transcription factors and is
indispensable for the establishment of definitive hematopoiesis in vertebrates. RUNX1 is …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Epigenetic enzymes are often dysregulated in human tumors through mutation, altered
expression, or inappropriate recruitment to certain loci. The identification of these enzymes …

Chemotherapy is one of the most established and effective treatments for almost all types of
cancer. However, the elevated toxicity due to the non-tumor-associated effects, development …

Normal hematopoiesis requires the accurate orchestration of lineage-specific patterns of
gene expression at each stage of development, and epigenetic regulators play a vital role …

Thyroid hormones (THs) play critical roles in the differentiation, growth, metabolism, and
physiological function of virtually all tissues. TH binds to receptors that are ligand …

Histone deacetylases (HDACs) play important roles in transcriptional regulation and
pathogenesis of cancer. Thus, HDAC inhibitors are candidate drugs for differentiation …

▪ Abstract Human leukemias are typified by acquired recurring chromosomal translocations.
Cloning of these translocation breakpoints has provided important insights into …

Although improvement in outcomes has occurred in younger adults with acute myeloid
leukemia (AML) during the past 4 decades, progress in older adults has been much less …

Abstract BACKGROUND Histone deacetylase 1 (HDAC1) is a co‐repressor involved in
differentiation and proliferation control. It is upregulated in malignant compared to benign …