Asthma is a chronic inflammatory airway disease resulting in airflow obstruction, which in
part can become irreversible to conventional therapies, defining the concept of airway …

COVID-19 is causing a major once-in-a-century global pandemic. The scientific and clinical
community is in a race to define and develop effective preventions and treatments. The …

Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …

Background Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus
disease-2019 (COVID-19) is a pandemic disease that affects> 2.8 million people worldwide …

Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of
type-I interferons, which have essential antiviral activities, including against SARS-CoV-2 …

Increased iron levels and dysregulated iron homeostasis, or both, occur in several lung
diseases. Here, the effects of iron accumulation on the pathogenesis of pulmonary fibrosis …

The extracellular matrix (ECM) is the scaffold that provides structure and support to all
organs, including the lung; however, it is also much more than this. The ECM provides …

Severe steroid-resistant asthma is clinically important, as patients with this form of the
disease do not respond to mainstay corticosteroid therapies. The heterogeneity of this form …

Asthma increases worldwide without any definite reason and patient numbers double every
10 years. Drugs used for asthma therapy relax the muscles and reduce inflammation, but …

Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …