Cyclosporine A (CsA) is a widely used immunosuppressive agent that greatly reduces the
rates of kidney-, heart-, and liver-transplant rejection. However, CsA nephrotoxicity is a …

Toxins are natural or chemical poisonous substances with severe side effects on health.
Humans are generally exposed by widespread toxic contaminations via air, soil, water, food …

Background Cisplatin (CP) is known as a potent anti-cancer drug. The most therapeutic
adverse effect of CP is induced hepatotoxicity. In the present study, the protective effect of …

Cisplatin nephropathy can be regarded as a mitochondrial disease. Intervention to halt such
deleterious injury is under investigation. Recently, the flavanol (–)-epicatechin emerges as a …

Background: Polygonum cuspidatum Siebold & Zucc.(PCS) has antibacterial properties and
may prevent Ulcerative colitis (UC) but related molecular mechanism remains unknown. NF …

NF-kB plays a major role in the aetiopathogenesis of inflammatory-colitis. In this study, we
evaluated the efficacy of green tea and its polyphenols and their nanoformulation in Tri-Nitro …

Cyclosporine A (CsA) is a potent immunosuppressor that is widely used in transplant
surgery and the treatment of several autoimmune diseases. However, major side effects of …

Aim: Although the pathogenesis of cyclosporine (CsA) nephropathy is not completely
understood, it is attributed to oxidative damage and apoptosis. Grape seed …

To investigate the effect of pomegranate juice (PJ) on the cyclosporine (CsA)-induced
nephrotoxicity in rats, 80 rats were divided into four groups. The first group was regarded a …

Amikacin (AK) is an aminoglycoside that is widely used to treat life-threatening Gram-
negative infections, especially in intensive care units. Despite its wide clinical indications …