The control of apoptosis in mammals has been historically associated with the activity of the
BCL-2 family of proteins at the mitochondria. In the past years, a novel group of cell death …

Abstract Bax inhibitor-1 (BI1) conveys anti-apoptotic signals for mitochondria while prohibitin
2 (PHB2) is implicated in sustaining mitochondrial morphology and function. However, their …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel inducer to promote
mitochondrial apoptosis and suppress tumor growth in a variety of cells although its role in …

Background Mitochondrial fission has been identified as the pathogenesis underlying the
development of cardiac microvascular ischemia reperfusion (IR) injury, although the …

Cellular gatekeepers are essential to maintain order within a cell and anticipate signals of
stress to promote survival. BCL2 associated X, apoptosis regulator (BAX) inhibitor‐1 (BI‐1) …

Pathogenesis of cardiac microvascular ischemia‐reperfusion (IR) injury is associated with
excessive mitochondrial fission. However, the upstream mediator of mitochondrial fission …

Lysosomal Ca2+ contributes to macroautophagy/autophagy, an intracellular process for the
degradation of cytoplasmic material and organelles in the lysosomes to protect cells against …

TMBIM6 is an endoplasmic reticulum (ER) protein that modulates various physiological and
pathological processes, including metabolism and cancer. However, its involvement in bone …

Global increases in coral disease prevalence have been linked to ocean warming through
changes in coral‐associated bacterial communities, pathogen virulence and immune system …

The importance of death receptor (DR) signaling in embryonic development and
physiological homeostasis is well established, as is the existence of several molecules that …