Next-generation stem cells—ushering in a new era of cell-based therapies

EA Kimbrel, R Lanza - Nature Reviews Drug Discovery, 2020 - nature.com
Naturally occurring stem cells isolated from humans have been used therapeutically for
decades. This has primarily involved the transplantation of primary cells such as …

Epigenetics of modified DNA bases: 5-methylcytosine and beyond

S Kumar, V Chinnusamy, T Mohapatra - Frontiers in genetics, 2018 - frontiersin.org
Modification of DNA bases plays vital roles in the epigenetic control of gene expression in
both animals and plants. Though much attention is given to the conventional epigenetic …

Optogenetics: background, methodological advances and potential applications for cardiovascular research and medicine

J Joshi, M Rubart, W Zhu - Frontiers in bioengineering and …, 2020 - frontiersin.org
Optogenetics is an elegant approach of precisely controlling and monitoring the biological
functions of a cell, group of cells, tissues, or organs with high temporal and spatial resolution …

Shedding light on neurons: optical approaches for neuromodulation

S Jiang, X Wu, NJ Rommelfanger, Z Ou… - National Science …, 2022 - academic.oup.com
Today's optical neuromodulation techniques are rapidly evolving, benefiting from advances
in photonics, genetics and materials science. In this review, we provide an up-to-date …

Animal functional magnetic resonance imaging: trends and path toward standardization

F Mandino, DH Cerri, CM Garin, M Straathof… - Frontiers in …, 2020 - frontiersin.org
Animal whole-brain functional magnetic resonance imaging (fMRI) provides a non-invasive
window into brain activity. A collection of associated methods aims to replicate observations …

The body electric 2.0: recent advances in developmental bioelectricity for regenerative and synthetic bioengineering

J Mathews, M Levin - Current opinion in biotechnology, 2018 - Elsevier
Breakthroughs in biomedicine and synthetic bioengineering require predictive, rational
control over anatomical structure and function. Recent successes in manipulating cellular …

Light‐controlled mammalian cells and their therapeutic applications in synthetic biology

M Mansouri, T Strittmatter, M Fussenegger - Advanced Science, 2019 - Wiley Online Library
The ability to remote control the expression of therapeutic genes in mammalian cells in order
to treat disease is a central goal of synthetic biology‐inspired therapeutic strategies …

Gene delivery approaches for mesenchymal stem cell therapy: strategies to increase efficiency and specificity

GS Oggu, S Sasikumar, N Reddy, KKR Ella… - Stem cell reviews and …, 2017 - Springer
A significant number of clinical trials have been undertaken to explore the use of
mesenchymal stem cells (MSCs) for the treatment of several diseases such as Crohn's …

Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience

J Bossuyt, Y Van Den Herrewegen, L Nestor, A Buckinx… - Glia, 2023 - Wiley Online Library
Insights into the role astrocytes and microglia play in normal and diseased brain functioning
has expanded drastically over the last decade. Recently, chemogenetic tools have emerged …

Tailoring light delivery for optogenetics by modal demultiplexing in tapered optical fibers

M Pisanello, F Pisano, L Sileo, E Maglie, E Bellistri… - Scientific reports, 2018 - nature.com
Optogenetic control of neural activity in deep brain regions ideally requires precise and
flexible light delivery with non-invasive devices. To this end, Tapered Optical Fibers (TFs) …