Diarylmethanon, bromophenol and diarylmethane compounds: Discovery of potent aldose reductase, α-amylase and α-glycosidase inhibitors as new therapeutic …
Diabetes mellitus (DM) is a chronic metabolic disease in which there are high blood sugar
levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase …
levels over a prolonged period. Aldose reductase (AR) belongs to aldo-keto reductase …
Molecular docking and inhibition studies of vulpinic, carnosic and usnic acids on polyol pathway enzymes
Aldose reductase (AR) and sorbitol dehydrogenase (SDH) are important enzymes of the
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
polyol pathway. In the current study, inhibitory effects of vulpinic acid (VA) carnosic acid (CA) …
N‐substituted phthalazine sulfonamide derivatives as non‐classical aldose reductase inhibitors
Abstract Aldose reductase (AR, AKR1B1; EC 1.1. 1.21) is an aldo‐keto reductase that has
been widely investigated as an enzyme crucially involved in the pathogenesis of several …
been widely investigated as an enzyme crucially involved in the pathogenesis of several …
Design, synthesis, in vitro and in silico investigation of aldose reductase inhibitory effects of new thiazole-based compounds
Aldose reductase (AR) catalyzes the NADPH-dependent reduction of glucose to sorbitol in
the polyol pathway, which plays an important role in the development of diabetic …
the polyol pathway, which plays an important role in the development of diabetic …
Hepatoprotection of capsaicin in alcoholic and non-alcoholic fatty liver diseases
E Karimi-Sales, G Mohaddes… - Archives of Physiology …, 2024 - Taylor & Francis
Alcoholic liver disease (ALD) and non-alcoholic fatty liver disease (NAFLD) are common
causes of chronic liver disease that share the range of steatosis, steatohepatitis, fibrosis …
causes of chronic liver disease that share the range of steatosis, steatohepatitis, fibrosis …
Antidiabetic potential: In vitro inhibition effects of bromophenol and diarylmethanones derivatives on metabolic enzymes
Aldose reductase converts glucose to sorbitol in the polyol pathway. It is an important
enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of …
enzyme to prevent diabetic complications. In this study, we studied the inhibitory effects of …
Benzenesulfonamide derivatives containing imine and amine groups: Inhibition on human paraoxonase and molecular docking studies
Sulfonamides known as inhibitors of many metabolic enzymes have been widely used as
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
antimicrobial drugs for a long time. In the present study, we investigated in vitro inhibitory …
Inhibition effects of quinones on aldose reductase: antidiabetic properties
Diabetes mellitus is a chronic metabolic disease characterized by abnormal glucose
metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts …
metabolism. Aldose reductase (AR) is the first enzyme in the polyol pathway and converts …
Exploration of some bis‐sulfide and bis‐sulfone derivatives as non‐classical aldose reductase inhibitors
Abstract Aldose reductase (AR, ALR2; EC 1.1. 1.21), an enzyme that converts glucose to
fructose on the polyol pathway, is an important member of the Aldo‐keto reductase …
fructose on the polyol pathway, is an important member of the Aldo‐keto reductase …
Screening and characterization of aldose reductase inhibitors from Traditional Chinese medicine based on ultrafiltration-liquid chromatography mass spectrometry …
H Zhang, C Xu, Q Tian, Y Zhang, G Zhang… - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Shenqi Jiangtang granule (SJG) is an ancient
Chinese herbal formula used for treatment of Diabetes mellitus and its complications. Aim of …
Chinese herbal formula used for treatment of Diabetes mellitus and its complications. Aim of …