Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …

Voltage-gated ion channels share a common structure typified by peripheral, voltage sensor
domains. Their S4 segments respond to alteration in membrane potential with translocation …

Genetic variants of gene SCN5A encoding the alpha-subunit of cardiac voltage-gated
sodium channel Nav1. 5 are associated with various diseases, including long QT syndrome …

Cardiac voltage‐gated ion channels (VGICs) play critical roles in mediating cardiac
electrophysiological signals, such as action potentials, to maintain normal heart excitability …

The delivery of kilohertz frequency alternating current (KHFAC) generates rapid, controlled,
and reversible conduction block in motor, sensory, and autonomic nerves, but causes …

ABSTRACT The segment 4 (S4) voltage sensor in voltage-gated sodium channels (Navs)
have domain-specific functions, and the S4 segment in domain DIV (DIVS4) plays a key role …

Background SCN5A mutations are associated with multiple arrhythmic and cardiomyopathic
phenotypes including Brugada syndrome (BrS), sinus node dysfunction (SND) …

Background Gain-of-function mutations in CACNA1C encoding Cav1. 2 cause syndromic or
non-syndromic type-8 long QT syndrome (LQTS)(sLQT8 or nsLQT8). The cytoplasmic …

Background The epinephrine infusion test (EIT) typically induces marked QT prolongation in
LQT1, but not LQT3, while the efficacy of β‐blocker therapy is established in LQT1, but not …

Abstract Cardiac voltage-gated Nav1. 5 sodium channels are responsible for initiation and
propagation of action potentials in cardiomyocytes. Nav1. 5 dysfunction may be due to both …