Abstract α‐Synucleinopathies are neurodegenerative diseases that are characterized
pathologically by α‐synuclein inclusions in neurons and glia. The pathologic contribution of …

The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their
tissue and molecular targets are poorly understood. In this study, we leveraged systems …

Metabolomics is a developing and promising tool for exploring molecular pathways
underlying symptoms of depression and predicting depression recovery. The Absolute …

Aberrant brain iron deposition is observed in both common and rare neurodegenerative
disorders, including those categorized as Neurodegeneration with Brain Iron Accumulation …

BACKGROUND Major depressive disorder (MDD) is a common and serious mental illness.
Many novel genes in MDD have been characterized by high-throughput methods such as …

Huntington's disease (HD) is the primary cause of progressive motor deficits, psychiatric
symptoms, and cognitive impairment. The exact molecular mechanisms of HD pathogenesis …

Introduction Hereditary spastic paraplegia is a group of inherited neurological disorders with
predominant manifestations of lower extremity weakness and severe spasticity. This is a …

In mammalian cells, lipids are the second major component of cellular mass and serve as
structural components and building blocks of cellular membranes. However, lipids are also …

The health impacts of endocrine-disrupting chemicals (EDCs) remain debated, and their
tissue and molecular targets are poorly understood. In this study, we leveraged systems …

Whole genome sequencing can enable an unbiased approach to the diagnosis and to the
understanding of genetic aetiology of neurodegenerative diseases, which are a clinically …