Discovery and implications of polygenicity of common diseases
The sequencing of the human genome has allowed the study of the genetic architecture of
common diseases: the number of genomic variants that contribute to risk of disease and …
common diseases: the number of genomic variants that contribute to risk of disease and …
[HTML][HTML] Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals
We conduct a genome-wide association study (GWAS) of educational attainment (EA) in a
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
sample of~ 3 million individuals and identify 3,952 approximately uncorrelated genome …
Research Review: A guide to computing and implementing polygenic scores in developmental research
AG Allegrini, JR Baldwin, W Barkhuizen… - Journal of Child …, 2022 - Wiley Online Library
The increasing availability of genotype data in longitudinal population‐and family‐based
samples provides opportunities for using polygenic scores (PGS) to study developmental …
samples provides opportunities for using polygenic scores (PGS) to study developmental …
Genome-wide analyses of individual differences in quantitatively assessed reading-and language-related skills in up to 34,000 people
E Eising, N Mirza-Schreiber… - Proceedings of the …, 2022 - National Acad Sciences
The use of spoken and written language is a fundamental human capacity. Individual
differences in reading-and language-related skills are influenced by genetic variation, with …
differences in reading-and language-related skills are influenced by genetic variation, with …
[HTML][HTML] Calculating polygenic risk scores (PRS) in UK Biobank: a practical guide for epidemiologists
A polygenic risk score estimates the genetic risk of an individual for some disease or trait,
calculated by aggregating the effect of many common variants associated with the condition …
calculated by aggregating the effect of many common variants associated with the condition …
[HTML][HTML] Overcoming attenuation bias in regressions using polygenic indices
Measurement error in polygenic indices (PGIs) attenuates the estimation of their effects in
regression models. We analyze and compare two approaches addressing this attenuation …
regression models. We analyze and compare two approaches addressing this attenuation …
The Dunedin study after half a century: reflections on the past, and course for the future
Over the last 50 years Dunedin Study researchers have published more than 1400 peer-
reviewed journal articles, books, and reports on many aspects of human health and …
reviewed journal articles, books, and reports on many aspects of human health and …
[HTML][HTML] Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
[HTML][HTML] The impact of entrepreneurship research on other academic fields
The remarkable ascent of entrepreneurship witnessed as a scientific field over the last 4
decades has been made possible by entrepreneurship's ability to absorb theories …
decades has been made possible by entrepreneurship's ability to absorb theories …
[HTML][HTML] Schooling substantially improves intelligence, but neither lessens nor widens the impacts of socioeconomics and genetics
Abstract Schooling, socioeconomic status (SES), and genetics all impact intelligence.
However, it is unclear to what extent their contributions are unique and if they interact. Here …
However, it is unclear to what extent their contributions are unique and if they interact. Here …