Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
Development of multifunctional molecules as potential therapeutic candidates for Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis in the …
Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …
HSP70 chaperones RNA-free TDP-43 into anisotropic intranuclear liquid spherical shells
INTRODUCTION Aggregation of the RNA binding protein TDP-43 (TAR DNA-binding protein
43) is a common pathological hallmark shared by several age-related neurodegenerative …
43) is a common pathological hallmark shared by several age-related neurodegenerative …
[HTML][HTML] RNA binding antagonizes neurotoxic phase transitions of TDP-43
TDP-43 proteinopathy is a pathological hallmark of amyotrophic lateral sclerosis and
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …
frontotemporal dementia where cytoplasmic TDP-43 inclusions are observed within …
TDP-43 α-helical structure tunes liquid–liquid phase separation and function
Liquid–liquid phase separation (LLPS) is involved in the formation of membraneless
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …
organelles (MLOs) associated with RNA processing. The RNA-binding protein TDP-43 is …
Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis
K Oiwa, S Watanabe, K Onodera, Y Iguchi… - Science …, 2023 - science.org
The cytoplasmic aggregation of TAR DNA binding protein-43 (TDP-43), also known as TDP-
43 pathology, is the pathological hallmark of amyotrophic lateral sclerosis (ALS). However …
43 pathology, is the pathological hallmark of amyotrophic lateral sclerosis (ALS). However …
A single N‐terminal phosphomimic disrupts TDP‐43 polymerization, phase separation, and RNA splicing
TDP‐43 is an RNA‐binding protein active in splicing that concentrates into membraneless
ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and …
ribonucleoprotein granules and forms aggregates in amyotrophic lateral sclerosis (ALS) and …
Prion-like propagation of protein misfolding and aggregation in amyotrophic lateral sclerosis
The discovery that prion protein can misfold into a pathological conformation that encodes
structural information capable of both propagation and inducing severe neuropathology has …
structural information capable of both propagation and inducing severe neuropathology has …
Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties
ZR Grese, ACS Bastos, LD Mamede, RL French… - EMBO …, 2021 - embopress.org
TDP‐43 is an RNA‐binding protein that forms ribonucleoprotein condensates via liquid‐
liquid phase separation (LLPS) and regulates gene expression through specific RNA …
liquid phase separation (LLPS) and regulates gene expression through specific RNA …
TDP-43 pathology: from noxious assembly to therapeutic removal
Our understanding of amyotrophic lateral sclerosis and frontotemporal dementia has
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …
advanced dramatically since the discovery of cytoplasmic TAR DNA-binding protein 43 (TDP …