This review provides an extensive summary of the effects of carbohydrate fluorination with
regard to changes in physical, chemical and biological properties with respect to regular …

The review covers various aspects of fluorinated cycloalkyl (C3− C7) building blocks for drug
discovery, including their synthesis, key physicochemical properties, and biological and …

Optimization of compound lipophilicity is a key aspect of drug discovery. The aim of this work
was to compare the lipophilicity modulations induced by 16 distinct known and novel …

1, 1-Disubstituted styrenes with internal oxygen and nitrogen nucleophiles undergo
oxidative fluorocyclization reactions with in situ generated chiral iodine (III)-catalysts. The …

Galectins are potential biomarkers and therapeutic targets. However, galectins display
broad affinity towards β-galactosides meaning glycan-based (nano) biosensors lack the …

Modulation of the H-bond basicity (p K HB) of various functional groups (FGs) by attaching
fluorine functions and its impact on lipophilicity and bioisosterism considerations are …

Fluorine atoms play an important role in all branches of chemistry and accordingly, it is very
important to study their unique and varied effects systematically, in particular, the structure …

We report a process to access a variety of enantioenriched α‐gem‐difluorinated alcohols. A
Rh (III)‐catalyzed asymmetric transfer hydrogenation method was developed in 85–98 …

Fluorinated carbohydrates, where one (or more) fluorine atom (s) have been introduced into
a carbohydrate structure, typically through deoxyfluorination chemistry, have a wide range of …

Combined molecular, physicochemical and chemical properties of electrophilic warheads
can be applied to create covalent drugs with diverse facets. Here we study these properties …