Tumor suppressor miRNA in cancer cells and the tumor microenvironment: mechanism of deregulation and clinical implications
K Otmani, P Lewalle - Frontiers in oncology, 2021 - frontiersin.org
MicroRNAs (miRNAs) are noncoding RNAs that have been identified as important
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
posttranscriptional regulators of gene expression. miRNAs production is controlled at …
[HTML][HTML] DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma
IA González, DR Stewart, KAP Schultz, AP Field… - Modern Pathology, 2022 - Elsevier
Abstract DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial
tumor predisposition disorder with a heterozygous DICER1 germline mutation. The most …
tumor predisposition disorder with a heterozygous DICER1 germline mutation. The most …
The disparate origins of ovarian cancers: pathogenesis and prevention strategies
Ovarian cancer is the fifth cause of cancer-related death in women and comprises a
histologically and genetically broad range of tumours, including those of epithelial, sex cord …
histologically and genetically broad range of tumours, including those of epithelial, sex cord …
Ovarian cancers: genetic abnormalities, tumor heterogeneity and progression, clonal evolution and cancer stem cells
Four main histological subtypes of ovarian cancer exist: serous (the most frequent),
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …
endometrioid, mucinous and clear cell; in each subtype, low and high grade. The large …
DICER1 mutations are consistently present in moderately and poorly differentiated Sertoli-Leydig cell tumors
L de Kock, T Terzic, WG McCluggage… - The American journal …, 2017 - journals.lww.com
Abstract Ovarian Sertoli-Leydig cell tumors (SLCTs) are uncommon sex cord-stromal tumors
associated with both germ-line and somatic DICER1 mutations, the frequency of which has …
associated with both germ-line and somatic DICER1 mutations, the frequency of which has …
ETMR: a tumor entity in its infancy
Abstract Embryonal tumor with Multilayered Rosettes (ETMR) is a relatively rare but typically
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …
deadly type of brain tumor that occurs mostly in infants. Since the discovery of the …
Ten years of DICER1 mutations: Provenance, distribution, and associated phenotypes
L de Kock, MK Wu, WD Foulkes - Human Mutation, 2019 - Wiley Online Library
DICER1 syndrome is a pleiotropic tumor predisposition syndrome characterized by a
distinctive constellation of neoplastic and dysplastic lesions, which are generally rare and …
distinctive constellation of neoplastic and dysplastic lesions, which are generally rare and …
DICER1-related Sertoli-Leydig cell tumor and gynandroblastoma: Clinical and genetic findings from the International Ovarian and Testicular Stromal Tumor Registry
Background Ovarian sex cord-stromal tumors (OSCST) include juvenile granulosa cell
tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among …
tumors (JGCT), Sertoli-Leydig cell tumor (SLCT) and gynandroblastoma (GAB) among …
An update on the central nervous system manifestations of DICER1 syndrome
L de Kock, JR Priest, WD Foulkes… - Acta neuropathologica, 2020 - Springer
DICER1 syndrome is a rare tumor predisposition syndrome with manifestations that
predominantly affect children and young adults. The syndrome is typically caused by …
predominantly affect children and young adults. The syndrome is typically caused by …
Mechanisms controlling microRNA expression in tumor
S Chen, Y Wang, D Li, H Wang, X Zhao, J Yang… - Cells, 2022 - mdpi.com
MicroRNAs (miRNAs) are widely present in many organisms and regulate the expression of
genes in various biological processes such as cell differentiation, metabolism, and …
genes in various biological processes such as cell differentiation, metabolism, and …