PLK1 is an evolutionary conserved Ser/Thr kinase that is best known for its role in cell cycle
regulation and is expressed predominantly during the G2/S and M phase of the cell cycle …

Activity-based protein profiling (ABPP) is a technique that uses highly selective active-site
targeted chemical probes to label and monitor the state of proteins. ABPP integrates the …

Reflecting its pleiotropic functions, Polo-like kinase 1 (PLK1) localizes to various sub-cellular
structures during mitosis. At kinetochores, PLK1 contributes to microtubule attachments and …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

Hepatic ischemia-reperfusion injury (IRI) is a common complication occurs during hepatic
resection and transplantation. However, the mechanisms underlying hepatic IRI have not …

Multiple kinases and phosphatases act on the kinetochore to control chromosome
segregation: Aurora B, Mps1, Bub1, Plk1, Cdk1, PP1, and PP2A-B56, have all been shown …

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote
chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly …

Simple Summary This review summarizes the current DUBs findings that correlate with the
most common cancers in the world (liver, breast, prostate, colorectal, pancreatic, and lung …

The cell division cycle is driven by a collection of enzymes that coordinate DNA duplication
and separation, ensuring that genomic information is faithfully and perpetually maintained …

Bub1 is required for the kinetochore/centromere localization of two essential mitotic kinases
Plk1 and Aurora B. Surprisingly, stable depletion of Bub1 by∼ 95% in human cells …