Organ transplantation is undergoing profound changes. Contraindications for donation have
been revised in order to better meet the organ demand. The use of lower-quality organs and …

The high demand for organs in kidney transplantation and the expansion of the donor pool
have led to the widespread implementation of machine perfusion technologies. In this study …

Static cold storage (SCS) and hypothermic machine perfusion (HMP) are two primary
options for renal allograft preservation. Compared with SCS, HMP decreased the incidence …

Ex-vivo machine perfusion represents a superior organ preservation method over static cold
storage. There is still an urgent need for the optimization of the perfusion fluid and machine …

Introduction: Delayed graft function (DGF) is a frequent complication after deceased donor
kidney transplantation with an impact on the prognosis of the transplant. Despite this, long …

Despite reduction in the rates of DGF by HMP, its effect on long-term renal and patient
outcomes is not clearly known. There is limited clinical literature in the use of normothermic …

Extracellular vesicles (EVs) play an important role in cell-to-cell communication by delivering
coding and non-coding RNA species and proteins to target cells. Recently, the therapeutic …

Background Nephrotoxicity of calcineurin inhibitors (CNIs) is the major concern for long-term
allograft survival despite its predominant role in current immunosuppressive regime after …

Interstitial fibrosis with tubule atrophy (IF/TA) is the response to virtually any sustained
kidney injury and correlates inversely with kidney function and allograft survival. IF/TA is …

Background. The results of kidney transplantation are impacted by the categories of events
responsible for patient death and graft failure. The objective of this study was to evaluate the …