With the success of immune checkpoint inhibitors (ICIs), significant progress has been made
in the field of cancer immunotherapy. Despite the long-lasting outcomes in responders, the …

The tumor microenvironment is a complex system, playing an important role in tumor
development and progression. Besides cellular stromal components, extracellular matrix …

Recombinant interferon‐α (IFN‐α) was approved by regulatory agencies in many countries
in 1986. As the first biotherapeutic approved, IFN‐α paved the way for the development of …

The liver is a unique anatomical and immunological site in which antigen‐rich blood from
the gastrointestinal tract is pressed through a network of sinusoids and scanned by antigen …

▪ Abstract The Class 2 α-helical cytokines consist of interleukin-10 (IL-10), IL-19, IL-20, IL-22,
IL-24 (Mda-7), and IL-26, interferons (IFN-α,-β,-ε,-κ,-ω,-δ,-τ, and-γ) and interferon-like …

The T-cell biology of the liver is unlike that of any other organ. The local lymphocyte
population is enriched in natural killer (NK) and NKT cells, which might have crucial roles in …

The 'liver tolerance effect'mediates local and systemic tolerance to self and foreign antigens
and has been attributed to specialized resident cells expressing anti-inflammatory mediators …

Dendritic cells are the professional antigen-presenting cells of the immune system. To
induce an effective immune response, these cells should not only express high levels of …

To examine the impact of tumors on the immune system, we compared global gene
expression profiles of peripheral blood T cells from previously untreated patients with B cell …

Abstract Interleukin (IL)-10 is a pleiotropic cytokine produced by both T cells and
macrophages and possesses both anti-inflammatory and immunosuppressive properties. IL …