Genomic stability in normal cells is crucial to avoid oncogenesis. Accordingly, multiple
components of the DNA damage response (DDR) operate as bona fide tumor suppressor …

Background: Multiplex tissue analysis has revolutionized our understanding of the tumor
microenvironment (TME) with implications for biomarker development and diagnostic …

Whereas the contribution of tumor microenvironment to the profound immune suppression of
glioblastoma (GBM) is clear, tumor-cell intrinsic mechanisms that regulate resistance to CD8 …

Abstract Purpose: This was a Phase I/II trial of the novel checkpoint kinase 1 (Chk1) inhibitor
SRA737 given in combination with gemcitabine. Its objectives were to establish the safety …

Oral squamous cell carcinoma (OSCC) is one of the most common head and neck
squamous cell carcinomas (HNSCC) globally. Its incidence rate is rapidly increasing, and its …

Simple Summary Synthetic lethality approaches to cancer therapy involves combining
events to cause cancer cell death. Using this strategy, major advances have occurred in the …

Head and neck squamous cell carcinomas (HNSCC) develop in the mucosal lining of the
upper-aerodigestive tract. In carcinogen-induced HNSCC, tumors emerge from …

Head and neck squamous cell carcinoma (HNSCC) has one of the most hypoxic and
immunosuppressive tumor microenvironments (TME) among solid tumors. However, there is …

Platinum-resistant ovarian cancer is difficult to treat and has a poor prognosis. Patients with
platinum-resistant ovarian cancer have limited treatment options and often have a limited …

RAS genes are known to be dysregulated in cancer for several decades, and substantial
effort has been dedicated to develop agents that reduce RAS expression or block RAS …