Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

To facilitate scalable profiling of single cells, we developed split-pool ligation-based
transcriptome sequencing (SPLiT-seq), a single-cell RNA-seq (scRNA-seq) method that …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

Sensory functions of the vagus nerve are critical for conscious perceptions and for
monitoring visceral functions in the cardio-pulmonary and gastrointestinal systems. Here, we …

The primary sensory system requires the integrated function of multiple cell types, although
its full complexity remains unclear. We used comprehensive transcriptome analysis of 622 …

Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Phenomena such as placebo analgesia or pain relief through distraction highlight the
powerful influence cognitive processes and learning mechanisms have on the way we …

The mammalian nervous system encodes many different forms of pain, from those that arise
as a result of short-term low-grade interactions with noxious thermal, chemical, or …

The multimodal properties of the human somatosensory system continue to be unravelled.
There is mounting evidence that one of these submodalities—touch—has another …