A machine learning-guided framework to unravel determinants of G-protein selectivity in GPCRs

G Singh - 2021 - archiv.ub.uni-heidelberg.de
Genetic variations can have positive, negative, or neutral impacts on protein interactions,
thus making it essential to understand them to obtain a mechanistic picture of biological …

[PDF][PDF] STRUCTURAL INSIGHTS INTO GPCR ACTIVATION: FROM RHODOPSIN TO CLASS A GPCRS

R Kumar - ENCYCLOPAEDIA OF VITAL PROTEINS - wisdompress.co.in
Bovine rhodopsin has served as the main resource for detailed structural understandings
into the realm of G Protein-Coupled Receptors (GPCRs) since the year 2000. Rhodopsin …

Comparison of Calcium and cAMP Measurements for the Screening of Corticotropin Releasing Factor Receptor Antagonists

S Park, S Lee - International Information Institute (Tokyo) …, 2017 - search.proquest.com
The calcium and cAMP assay were applied to the screening of natural product library for
corticotropin releasing factor (CRF) receptor antagonists. Total primary screening hits from …

[PDF][PDF] Differential Assay Performance between Direct and Indirect Functional Measurements for the G Protein Coupled Receptor

S Park, S Lee - 2016 - scholar.archive.org
For the screening of corticotropin releasing factor receptor subtype 1 (CRF1) and subtype 2
(CRF2) antagonists, 160 samples of natural product subset library was applied in the format …