The biology of ependymomas and emerging novel therapies

AH Saleh, N Samuel, K Juraschka, MH Saleh… - Nature Reviews …, 2022 - nature.com
Ependymomas are rare central nervous system tumours that can arise in the brain's
supratentorial region or posterior fossa, or in the spinal cord. In 1924, Percival Bailey …

The oncogenic fusion landscape in pediatric CNS neoplasms

M Roosen, Z Odé, J Bunt, M Kool - Acta Neuropathologica, 2022 - Springer
Pediatric neoplasms in the central nervous system (CNS) are the leading cause of cancer-
related deaths in children. Recent developments in molecular analyses have greatly …

Childhood supratentorial ependymomas with YAP1‐MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features

F Andreiuolo, P Varlet, A Tauziède‐Espariat… - Brain …, 2019 - Wiley Online Library
Ependymoma with YAP1‐MAMLD1 fusion is a rare, recently described supratentorial
neoplasm of childhood, with few cases published so far. We report on 15 pediatric patients …

Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion–positive supratentorial ependymomas

T Zheng, DR Ghasemi, K Okonechnikov, A Korshunov… - Cancer discovery, 2021 - AACR
Molecular groups of supratentorial ependymomas comprise tumors with ZFTA–RELA or
YAP1-involving fusions and fusion-negative subependymoma. However, occasionally …

Recurrent YAP1 and KMT2A gene rearrangements in a subset of MUC4-negative sclerosing epithelioid fibrosarcoma

YC Kao, JC Lee, L Zhang, YS Sung… - The American journal …, 2020 - journals.lww.com
Sclerosing epithelioid fibrosarcoma (SEF) is an aggressive soft tissue sarcoma,
characterized by a distinctive epithelioid phenotype in a densely sclerotic collagenous …

Molecular subtyping of ependymoma and prognostic impact of Ki-67

KY Lim, K Lee, Y Shim, JW Park, H Kim, J Kang… - Brain Tumor …, 2022 - Springer
Although ependymomas (EPNs) have similar histopathology, they are heterogeneous
tumors with diverse immunophenotypes, genetics, epigenetics, and different clinical …

Ependymoma‐like tumor with mesenchymal differentiation harboring C11orf95NCOA1/2 or ‐RELA fusion: A hitherto unclassified tumor related to ependymoma

R Tomomasa, Y Arai, R Kawabata‐Iwakawa… - Brain …, 2021 - Wiley Online Library
Recurrent fusion genes involving C11orf95, C11orf95‐RELA, have been identified only in
supratentorial ependymomas among primary CNS tumors. Here, we report hitherto …

Molecular stratification of childhood ependymomas as a basis for personalized diagnostics and treatment

M Zaytseva, L Papusha, G Novichkova, A Druy - Cancers, 2021 - mdpi.com
Simple Summary The current trend in neuropathology directs to the integrated histo-
molecular approach. The traditional concept of histological grade should be complemented …

Intracranial ependymomas: molecular insights and translation to treatment

A Lester, KL McDonald - Brain Pathology, 2020 - Wiley Online Library
Ependymomas are primary central nervous system tumors (CNS), arising within the
posterior fossa and supratentorial regions of the brain, and in the spine. Over the last …

A coordinated approach for the assessment of molecular subgroups in pediatric ependymomas using low-cost methods

GR de Sousa, RCP Lira… - Journal of Molecular …, 2021 - Springer
Although ependymoma (EPN) molecular subgroups have been well established by
integrated high-throughput platforms, low-and middle-income countries still need low-cost …