Restricting the intake of calories has been practiced as a method for increasing both the
length and quality of life for over 500years. Experimental work confirming the success of this …

Mammalian studies have shaped our understanding of the endocrine control of appetite and
body weight in vertebrates and provided the basic vertebrate model that involves central …

Running wheels are commonly employed to measure rodent physical activity in a variety of
contexts, including studies of energy balance and obesity. There is no consensus on the …

Background Obesity is a multifactorial disorder influenced by genetic and environmental
factors. Animal models of obesity are required to help us understand the signaling pathways …

The regulation of food intake in fish is a complex process carried out through several
different mechanisms in the central nervous system (CNS) with hypothalamus being the …

Orexins are hypothalamic neuropeptides that were initially identified in the rat brain as
endogenous ligands for an (previously) orphan G-protein-coupled receptor (GPCR). They …

Second only to the mouse and rat, the zebrafish is the most popular animal model in
biomedical research. Rapid embryonic development and transparent organogenesis give it …

Endocrine factors regulate food intake and growth, two interlinked physiological processes
critical for the proper development of organisms. Somatic growth is mainly regulated by …

The main objectives of this study were to investigate the dynamics of the cortisol stress
response and the underlying molecular regulation in adult zebrafish exposed to acute and …

Since its introduction as a genetic vertebrate model system approximately 30 years ago, the
focus of zebrafish research has increasingly shifted to questions that are also relevant for …