Wnt signaling pathway in aging-related tissue fibrosis and therapies

HH Hu, G Cao, XQ Wu, ND Vaziri, YY Zhao - Ageing research reviews, 2020 - Elsevier
Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer

N Li, X Zhang, J Zhou, W Li, X Shu, Y Wu… - Advanced Drug Delivery …, 2022 - Elsevier
A growing body of multiscale biomechanical studies has been proposed to highlight the
mechanical cues in the development of hepatic fibrosis and cancer. At the cellular level …

New insights into Hippo/YAP signaling in fibrotic diseases

MM Mia, MK Singh - Cells, 2022 - mdpi.com
Fibrosis results from defective wound healing processes often seen after chronic injury
and/or inflammation in a range of organs. Progressive fibrotic events may lead to permanent …

Liver fibrosis resolution: from molecular mechanisms to therapeutic opportunities

Q Pei, Q Yi, L Tang - International Journal of Molecular Sciences, 2023 - mdpi.com
The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

Role of the Hippo pathway in fibrosis and cancer

CL Kim, SH Choi, JS Mo - Cells, 2019 - mdpi.com
The Hippo pathway is the key player in various signaling processes, including organ
development and maintenance of tissue homeostasis. This pathway comprises a core …

Antioxidant therapy against TGF‐β/SMAD pathway involved in organ fibrosis

S Ghafouri‐Fard, A Askari, H Shoorei… - Journal of Cellular …, 2024 - Wiley Online Library
Fibrosis refers to excessive build‐up of scar tissue and extracellular matrix components in
different organs. In recent years, it has been revealed that different cytokines and …

[HTML][HTML] Morin alleviates aflatoxin B1-induced liver and kidney injury by inhibiting heterophil extracellular traps release, oxidative stress and inflammatory responses in …

X Gao, J Xu, L Jiang, W Liu, H Hong, Y Qian, S Li… - Poultry Science, 2021 - Elsevier
ABSTRACT Aflatoxin B1 (AFB1) is a secondary metabolite produced by Aspergillus flavus
and parasitic aspergillus, mainly existing in cereals, peanuts, corn, and other crops, which …

TIM‐4 interference in Kupffer cells against CCL4‐induced liver fibrosis by mediating Akt1/Mitophagy signalling pathway

H Wu, G Chen, J Wang, M Deng, F Yuan… - Cell …, 2020 - Wiley Online Library
Objectives T‐cell immunoglobulin domain and mucin domain‐4 (TIM‐4) is selectively
expressed on antigen‐presenting cells (APCs) and modulates various immune responses …

Natural marine and terrestrial compounds as modulators of matrix metalloproteinases-2 (MMP-2) and MMP-9 in Alzheimer's disease

L Ciccone, J Vandooren, S Nencetti, E Orlandini - Pharmaceuticals, 2021 - mdpi.com
Several studies have reported neuroprotective effects by natural products. A wide range of
natural compounds have been investigated, and some of these may play a beneficial role in …

TGF‐β1 mediated Smad signaling pathway and EMT in hepatic fibrosis induced by Nano NiO in vivo and in vitro

Q Zhang, X Chang, H Wang, Y Liu… - Environmental …, 2020 - Wiley Online Library
Abstract Nickel oxide nanoparticles (Nano NiO) bears hepatotoxicity, while whether it leads
to liver fibrosis remains unclear. The aim of this study was to establish the Nano NiO …