Sex and gender differences in risk, pathophysiology and complications of type 2 diabetes mellitus

A Kautzky-Willer, J Harreiter, G Pacini - Endocrine reviews, 2016 - academic.oup.com
The steep rise of type 2 diabetes mellitus (T2DM) and associated complications go along
with mounting evidence of clinically important sex and gender differences. T2DM is more …

Placental endocrine activity: adaptation and disruption of maternal glucose metabolism in pregnancy and the influence of fetal sex

C Stern, S Schwarz, G Moser, S Cvitic… - International journal of …, 2021 - mdpi.com
The placenta is an endocrine fetal organ, which secretes a plethora of steroid-and proteo-
hormones, metabolic proteins, growth factors, and cytokines in order to adapt maternal …

Endoplasmic reticulum stress and development of insulin resistance in adipose, skeletal, liver, and foetoplacental tissue in diabesity

R Villalobos-Labra, M Subiabre, F Toledo… - Molecular aspects of …, 2019 - Elsevier
Diabesity is an abnormal metabolic condition shown by patients with obesity that develop
type 2 diabetes mellitus. Patients with diabesity present with insulin resistance, reduced …

Effect of fetal sex on maternal and obstetric outcomes

M Al-Qaraghouli, YMV Fang - Frontiers in pediatrics, 2017 - frontiersin.org
Fetal sex plays an important role in modifying the course and complications related to
pregnancy and may also have an impact on maternal health and well-being both during and …

Fetoplacental oxygen homeostasis in pregnancies with maternal diabetes mellitus and obesity

G Desoye, AM Carter - Nature Reviews Endocrinology, 2022 - nature.com
Despite improvements in clinical management, pregnancies complicated by pre-existing
diabetes mellitus, gestational diabetes mellitus or obesity carry substantial risks for parent …

Maternal gestational diabetes mellitus associates with altered gut microbiome composition and head circumference abnormalities in male offspring

S Wang, Y Liu, WH Tam, JYL Ching, W Xu, S Yan… - Cell Host & Microbe, 2024 - cell.com
The impact of gestational diabetes mellitus (GDM) on maternal or infant microbiome
trajectory remains poorly understood. Utilizing large-scale longitudinal fecal samples from …

Pregnancies in diabetes and obesity: the capacity-load model of placental adaptation

G Desoye, JCK Wells - Diabetes, 2021 - Am Diabetes Assoc
Excess nutritional supply to the growing fetus, resulting from maternal diabetes and obesity,
is associated with increased risks of fetal maldevelopment and adverse metabolic conditions …

Prediction and prevention of Gestational Diabetes: an update of recent literature

MA Kennelly, FM McAuliffe - European Journal of Obstetrics & Gynecology …, 2016 - Elsevier
A diagnosis of Gestational Diabetes (GDM) confers adverse risk to the health of the mother
and fetus both in pregnancy and later life. The background rate in pregnancy varies between …

Birth weight in different etiologies of disorders of sex development

S Poyrazoglu, F Darendeliler, SF Ahmed… - The Journal of …, 2017 - academic.oup.com
Context: It is well established that boys are heavier than girls at birth. Although the cause of
birth weight (BW) difference is unknown, it has been proposed that it could be generated …

The impact of fetal sex on risk factors for gestational diabetes and related adverse pregnancy outcomes

G Seghieri, G Di Cianni, E Gualdani, A De Bellis… - Acta Diabetologica, 2022 - Springer
Aims To investigate whether fetal sex affects the impact of classical GDM risk factors on the
diagnosis of gestational diabetes (GDM) as well as on related adverse pregnancy outcomes …