The mouse has become the favorite mammalian model. Among the many reasons for this
privileged position of mice is their genetic proximity to humans, the possibilities of …

Genetic factors clearly contribute to exceptional longevity and healthy aging in humans, yet
the identification of the underlying genes remains a challenge. Longevity is a complex …

Despite the dramatic increase in human lifespan over the past century, there remains
pronounced variability in “health‐span,” or the period of time in which one is generally …

The goal of this review article is to provide a resource for longitudinal studies, using animal
models, directed at understanding and modifying the relationship between cognition and …

We previously reported that mouse strains with lower circulating insulin-like growth factor 1
(IGF1) level at 6 mo have significantly extended longevity. Here we report that strains with …

Growth hormone (GH) and insulin‐like growth factor (IGF) signaling regulates lifespan in
mice. The modulating effects of genetic background gained much attention because it was …

The somatotropic signaling pathway has been implicated in aging and longevity studies in
mice and other species. The physiology and lifespans of a variety of mutant mice, both …

Summary The African annual fish Nothobranchius furzeri emerged as a new model for age
research over recent years. Nothobranchius furzeri show an exceptionally short lifespan …

As the population of people aged 60 or older continues to rise, it has become increasingly
important to understand the molecular basis underlying age-related cognitive decline. In …

In many organisms, rapidly changing environmental conditions are inducing dramatic shifts
in diverse phenotypic traits with consequences for fitness and population viability. However …