Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Phospholipids are emerging as novel second messengers in plant cells. They are rapidly
formed in response to a variety of stimuli via the activation of lipid kinases or …

Abstract Phosphatidylinositol 4 phosphate [PI (4) P] is essential for secretion in yeast, but its
role in mammalian cells is unclear. Current paradigms propose that PI (4) P acts primarily as …

Background Phosphoinositides are required for the recruitment of many proteins to both the
plasma membrane and the endosome; however, their role in protein targeting to other …

Phosphoinositides account for only a tiny fraction of cellular phospholipids but are extremely
important in the regulation of the recruitment and activity of many signaling proteins in …

Phosphoinositides (PIs) constitute a minor fraction of total cellular lipids in all eukaryotic
cells. They fulfill many important functions through interaction with a wide range of cellular …

PtdIns4 P is the major precursor for the synthesis of the multifunctional plasma membrane
lipid, PtdIns (4, 5) P 2. Yet PtdIns4 P also functions as a regulatory lipid in its own right …

Phosphoinositides are lipids that are present in the cytoplasmic leaflet of a cell's plasma and
internal membranes and play pivotal roles in the regulation of a wide variety of cellular …

It is now well appreciated that derivatives of phosphatidylinositol (PtdIns) are key regulators
of many cellular processes in eukaryotes. Of particular interest are phosphoinositides (mono …

Phosphatidylinositol 4, 5-biphosphate (PI [4, 5] P2) has emerged as an important signaling
molecule in the membrane for regulating vesicle exo-and endocytosis and the …