Plasmids are self-replicative DNA elements that are transferred between bacteria. Plasmids
encode not only antibiotic resistance genes but also adaptive genes that allow their hosts to …

DNA supercoiling acts as a global and ancestral regulator of bacterial gene expression. In
this review, we advocate that it plays a pivotal role in host-pathogen interactions by …

An important antibiotic target, DNA gyrase is an essential bacterial enzyme that introduces
negative supercoils into DNA and relaxes positive supercoils accumulating in front of …

Two enzymes are responsible for maintaining supercoiling in the human pathogen
Streptococcus pneumoniae, gyrase (GyrA2GyrB2) and topoisomerase I. To attain diverse …

In cyanobacteria DNA supercoiling varies over the diurnal cycle and is integrated with
temporal programs of transcription and replication. We manipulated DNA supercoiling in …

Our understanding of the mechanisms of microgravity perception and response in
prokaryotes (Bacteria and Archaea) lag behind those which have been elucidated in …

The histone-like protein HU is a conserved nucleoid-associated protein that is involved in
the maintenance of the bacterial chromosome architecture. It is the only known nucleoid …

Topoisomerase I (TopoI) in Streptococcus pneumoniae, encoded by topA, is a suitable
target for drug development. Seconeolitsine (SCN) is a new antibiotic that specifically blocks …

Streptococcus pneumoniae is a major cause of disease and death that develops resistance
to multiple antibiotics. DNA topoisomerase I (TopoI) is a novel pneumococcal drug target …

The DNA topoisomerases gyrase and topoisomerase I as well as the nucleoid-associated
protein HU maintain supercoiling levels in Streptococcus pneumoniae, a main human …