The tumor necrosis factor (TNF) ligand and receptor superfamilies play an important role in
cell proliferation, survival, and death. Stimulating or inhibiting TNF superfamily signaling …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

REVIEW Apoptosis is a cell suicide mechanism that enables metazoans to control cell
number in tissues and to eliminate individual cells that threaten the animal's survival. Certain …

Neurotrophins are a family of closely related proteins that were identified initially as survival
factors for sensory and sympathetic neurons, and have since been shown to control many …

With the advent of dense maps of human genetic variation, it is now possible to detect
positive natural selection across the human genome. Here we report an analysis of over 3 …

Programmed cell death plays critical roles in a wide variety of physiological processes
during fetal development and in adult tissues. In most cases, physiological cell death occurs …

▪ Abstract Nerve growth factor (NGF) was discovered 50 years ago as a molecule that
promoted the survival and differentiation of sensory and sympathetic neurons. Its roles in …

It is well established that some chemotherapeutic agents and radiation therapy generate
reactive oxygen species (ROS) in patients during cancer therapy. Free radicals, particularly …

Neurons are specialized cells with a complex morphology that represent the functional unit
of the nervous system. They are generated in remarkable numbers, particularly in higher …

▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β,
and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF …