Increasing knowledge about molecular mechanisms of endogenous RNA interference
(RNAi) and small interfering RNAs (siRNAs) has been incorporated into innovative nucleic …

Since the discovery of the “starburst polymer”, later renamed as dendrimer, this class of
polymers has gained considerable attention for numerous biomedical applications, due …

The lack of an appropriate intracellular delivery system for therapeutic nucleic acids (TNAs)
is a major problem in molecular biology, biotechnology, and medicine. A relatively new class …

Efficient methods for cell line transfection are well described, but, for primary neurons, a high-
yield method different from those relying on viral vectors is lacking. Viral transfection has …

Small interfering RNAs (siRNAs) are capable of targeting and destroying specific mRNAs,
making them particularly suited to the treatment of neurodegenerative conditions such as …

Viral and synthetic vectors to deliver nucleic acids were key to the rapid development of
extraordinarily efficient COVID-19 vaccines. The four-component lipid nanoparticles (LNPs) …

Over the last decade, various nanomaterial systems have been developed as important and
powerful strategies to deliver conventional drugs, recombinant proteins, vaccines, aptamers …

Nanotechnology offers a new platform for therapeutic delivery of antiretrovirals to the central
nervous system (CNS). Nanoformulated antiretroviral drugs offer multifunctionality, that is …

RNA interference (RNAi) was first literaturally reported in 1998 and has become rapidly a
promising tool for therapeutic applications in gene therapy. In a typical RNAi process, small …

Introduction: The field of RNA interference technology has been researched extensively in
recent years. However, the development of clinically suitable, safe and effective drug …