A hyperinflammatory response during severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection crucially worsens clinical evolution of coronavirus disease 2019 …

COVID-19 is a clinical syndrome ranging from mild symptoms to severe pneumonia that
often leads to respiratory failure, need for mechanical ventilation, and death. Most of the lung …

Abstract Interleukin (IL)‐18 is a pro‐inflammatory cytokine belonging to the IL‐1 family, first
identified for its interferon‐γ‐inducing properties. IL‐18 regulates both T helper (Th) 1 and …

Myocardial infarction (MI) is the leading cause of death and morbidity worldwide, with an
incidence relatively high in developed countries and rapidly growing in developing …

Neutrophil extracellular traps (NETs) are formed by decondensed chromatin, histones, and
neutrophil granular proteins and have a role in entrapping microbial pathogens. NETs …

In the setting of myocardial infarction (MI), ischemia reperfusion injury (IRI) occurs due to
occlusion (ischemia) and subsequent re-establishment of blood flow (reperfusion) of a …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is capable of inducing the
activation of NACHT, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) …

The NLRP3 inflammasome has been implicated in the development and progression of
heart failure. The aim of this study was to determine the safety of an oral inhibitor of the …

Placental insufficiency and adipose tissue dysregulation are postulated to play key roles in
the pathophysiology of both pre-eclampsia (PE) and gestational diabetes mellitus (GDM). A …

Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity
worldwide. Atherosclerosis is responsible for the majority of cardiovascular disorders with …