Paradoxical roles of the immune system during cancer development

KE De Visser, A Eichten, LM Coussens - Nature reviews cancer, 2006 - nature.com
The main function of the mammalian immune system is to monitor tissue homeostasis, to
protect against invading or infectious pathogens and to eliminate damaged cells. Therefore …

Lymphocytes in cancer development: polarization towards pro-tumor immunity

B Ruffell, DG DeNardo, NI Affara… - Cytokine & growth factor …, 2010 - Elsevier
The classic view that the role of immune cells in cancer is primarily one of tumor rejection
has been supplanted by a more complex view of leukocytes having both pro-and anti-tumor …

Liver transplantation: the current situation

R Adam, E Hoti - Seminars in liver disease, 2009 - thieme-connect.com
Over the years, an improving liver transplant (LT) survival rate (1-and 5-year survival of 83%
and 75%, respectively) has been instrumental in establishing transplant surgery as a …

[PDF][PDF] Risk of malignant neoplasms after liver transplantation: a population‐based study

F Åberg, E Pukkala, K Höckerstedt… - Liver …, 2008 - Wiley Online Library
Posttransplant malignancies have become a serious long‐term complication after liver
transplantation. Our aim was to compare the incidence of posttransplant cancers with …

Liver transplantation: immunosuppression and oncology

M Rodríguez-Perálvarez, M De la Mata… - Current opinion in …, 2014 - journals.lww.com
Randomized controlled trials with sufficiently long follow-up are needed to evaluate the
influence of different immunosuppression protocols in preventing malignancy after LT …

[HTML][HTML] Extensive surveillance promotes early diagnosis and improved survival of de novo malignancies in liver transplant recipients

A Finkenstedt, IW Graziadei, W Oberaigner… - American Journal of …, 2009 - Elsevier
The aim of our study was to examine whether an extensive surveillance protocol will
promote early diagnosis and improved survival in patients with de novo cancer following …

[PDF][PDF] Incidence and long‐term risk of de novo malignancies after liver transplantation with implications for prevention and detection

H Schrem, M Kurok, A Kaltenborn, A Vogel… - Liver …, 2013 - Wiley Online Library
The goal of this study was the characterization of long‐term cancer risks after liver
transplantation (LT) with implications for prevention and detection. Site‐specific cancer …

Tobacco smoking and solid organ transplantation

C Corbett, MJ Armstrong, J Neuberger - Transplantation, 2012 - journals.lww.com
Smoking, both by donors and by recipients, has a major impact on outcomes after organ
transplantation. Recipients of smokers' organs are at greater risk of death (lungs hazard ratio …

[PDF][PDF] Liver transplantation in patients over 60 and 65 years: an evaluation of long‐term outcomes and survival

TJS Cross, CG Antoniades, P Muiesan… - Liver …, 2007 - Wiley Online Library
With increased demand for liver transplantation (LT), outcomes of older recipients have
been subjected to greater scrutiny, as previous studies have demonstrated poorer survival …

Bilirubin‐induced oxidative stress leads to DNA damage in the cerebellum of hyperbilirubinemic neonatal mice and activates DNA double‐strand break repair …

V Rawat, G Bortolussi, S Gazzin… - … medicine and cellular …, 2018 - Wiley Online Library
Unconjugated bilirubin is considered a potent antioxidant when present at moderate levels.
However, at high concentrations, it produces severe neurological damage and death …