An overview on synthetic 2-aminothiazole-based compounds associated with four biological activities

M Farouk Elsadek, B Mohamed Ahmed… - Molecules, 2021 - mdpi.com
Amongst sulfur-and nitrogen-containing heterocyclic compounds, the 2-aminothiazole
scaffold is one of the characteristic structures in drug development as this essential …

Recent advances in the discovery of novel antiprotozoal agents

SM Lee, MS Kim, F Hayat, D Shin - Molecules, 2019 - mdpi.com
Parasitic diseases have serious health, social, and economic impacts, especially in the
tropical regions of the world. Diseases caused by protozoan parasites are responsible for …

The oral acute toxicity of per-and polyfluoroalkyl compounds (PFASs) to Rat and Mouse: A mechanistic interpretation and prioritization analysis of untested PFASs by …

S Chen, T Fan, N Zhang, L Zhao, R Zhong… - Journal of Hazardous …, 2024 - Elsevier
Per-and polyfluoroalkyl substances (PFASs) are widely used in modern industry, causing
many adverse effects on both the environment and human health. In this study, for the first …

Prediction on the mutagenicity of nitroaromatic compounds using quantum chemistry descriptors based QSAR and machine learning derived classification methods

Y Hao, G Sun, T Fan, X Sun, Y Liu, N Zhang… - Ecotoxicology and …, 2019 - Elsevier
Nitroaromatic compounds (NACs) are an important type of environmental organic pollutants.
However, it is lack of sufficient information relating to their potential adverse effects on …

[PDF][PDF] SYNTHESIS OF 1, 3-THIAZOLE DERIVATIVES.

R Omar, P Koparir, M Koparir - Indian Drugs, 2021 - researchgate.net
Many heterocyclic compounds containing nitrogen atom are used in drug development.
Thiazole is one of the most important heterocyclic compounds in drug design, which …

Synthesis, in vitro antigiardial activity, SAR analysis and docking study of substituted chalcones

D Cáceres-Castillo, RM Carballo… - Medicinal Chemistry …, 2020 - Springer
A series of 15 chalcones-bearing substituents at positions 2, 4, and 5 of rings A and B were
synthesized using microwave-assisted Claissen–Smichdt condensation and evaluated for …

Development of 3D-QSAR and pharmacophoric models to design new anti-Trypanosoma cruzi agents based on 2-aryloxynaphthoquinone scaffold

M Paulino, C Espinosa-Bustos, J Bertrand… - SAR and QSAR in …, 2022 - Taylor & Francis
In this work we have collected a set of 30 trypanosomicidal naphthoquinones and
developed pharmacophoric and 3D-QSAR models as tools for the design of new potential …

Development of QSAR model for predicting the inclusion constants of organic chemicals with α-cyclodextrin

M Wei, X Yang, P Watson, F Yang, H Liu - Environmental Science and …, 2018 - Springer
Solubility is a crucial limiting factor in pharmaceutical research and contaminated site
remediation. Cyclodextrin, with its structure of hydrophilic exterior and hydrophobic cavity …

Synthesis and in vitro antiprotozoal activity of some 2-amino-4-phenyloxazole derivatives

RM Carballo, J Patrón-Vázquez… - Tropical Journal of …, 2017 - ajol.info
Purpose: To prepare some 2-amino-4-(p-substituted phenyl)-oxazole derivatives and to
evaluate their in vitro antiprotozoal activity against Giardia lamblia and Trichomonas …

Anti-protozoal potential of heterocyclic compounds against giardiasis

R Kaur Bhatia - Current Bioactive Compounds, 2019 - ingentaconnect.com
The aim of this literature review is to compile data of heterocyclic antigiardial agents. The
importance is to analyze the structural requirements for improved antigiardial activity, to …