Liver cell types derived from induced pluripotent stem cells (iPSCs) share the potential to
investigate development, toxicity, as well as genetic and infectious disease in ways currently …

Background Liver, as a vital organ, is responsible for a wide range of biological functions to
maintain homeostasis and any type of damages to hepatic tissue contributes to disease …

The circadian clock is an evolutionarily conserved timekeeper that adapts body physiology
to diurnal cycles of around 24 h by influencing a wide variety of processes such as sleep‐to …

The capacity of pluripotent stem cells both for self-renewal and to differentiate into any cell
type have made them a powerful tool for studying human disease. Protocols for efficient …

Mutations in POLG disrupt mt DNA replication and cause devastating diseases often with
neurological phenotypes. Defining disease mechanisms has been hampered by limited …

Human pluripotent stem cells (hPSCs) possess great value for biomedical research. hPSCs
can be scaled and differentiated to all cell types found in the human body. The differentiation …

Induced pluripotent stem cells (iPSCs) have become a prevalent topic after their discovery,
advertised as an ethical alternative to embryonic stem cells (ESCs). Due to their ability to …

Drug induced liver injury (DILI) is a major cause of acute liver failure (ALF) and one of the
leading indications for liver transplantation in Western societies. Given the wide use of both …

A variety of approaches have been developed for the derivation of hepatocyte-like cells from
pluripotent stem cells. Currently, most of these strategies employ step-wise differentiation …

The lack of physiological parity between 2D cell culture and in vivo culture has led to the
development of more organotypic models, such as organoids. Organoid models have been …