Isoforms of the casein kinase 1 (CK1) family have been shown to phosphorylate key
regulatory molecules involved in cell cycle, transcription and translation, the structure of the …

Anti‐cancer therapies targeting and damaging the DNA have been extensively used in the
last 50 years since the discovery of nitrogen mustards, antimetabolites and platin agents …

Definitive haematopoietic stem and progenitor cells (HSPCs) generate erythroid, lymphoid
and myeloid lineages. HSPCs are produced in the embryo via transdifferentiation of …

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that
is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to …

Assessment of the network of toxicity pathways by Omics technologies and bioinformatic
data processing paves the road toward a new toxicology for the twenty-first century …

Over the past decade, major leaps forward have been made on the mechanistic
understanding and identification of adaptive stress response landscapes underlying toxic …

Investigative toxicology describes the de-risking and mechanistic elucidation of toxicities,
supporting early safety decisions in the pharmaceutical industry. Recently, investigative …

In genetic toxicology, risk assessment has traditionally adopted linear dose–responses for
any compound that causes genotoxic effects. Increasing evidence of non-linear dose …

Analysis of transcriptome changes has become an established method to characterize the
reaction of cells to toxicants. Such experiments are mostly performed at compound …

DNA damage response signaling is crucial for genome maintenance in all organisms and is
corrupted in cancer. In an RNA interference (RNAi) screen for (de) ubiquitinases and …