Integrating muscle fiber orientation from visible human data into radiotherapy target volumes

G Buti, A Ajdari, YL Chen, CP Bridge… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. A major challenge in treatment of tumors near skeletal muscle is defining the
target volume for suspected tumor invasion into the muscle. This study develops a …

Diffusion tensor transformation for personalizing target volumes in radiation therapy

G Buti, A Ajdari, CP Bridge, GC Sharp, T Bortfeld - Medical Image Analysis, 2024 - Elsevier
Diffusion tensor imaging (DTI) is used in tumor growth models to provide information on the
infiltration pathways of tumor cells into the surrounding brain tissue. When a patient-specific …

The influence of anisotropy on the clinical target volume of brain tumor patients

G Buti, A Ajdari, K Hochreuter, H Shih… - Physics in Medicine …, 2024 - iopscience.iop.org
Objective. Current radiotherapy guidelines for glioma target volume definition recommend a
uniform margin expansion from the gross tumor volume (GTV) to the clinical target volume …

[HTML][HTML] Investigating the potential of diffusion tensor atlases to generate anisotropic clinical tumor volumes in glioblastoma patients

K Hochreuter, G Buti, A Ajdari, CP Bridge… - Physics and Imaging in …, 2024 - Elsevier
Background and purpose: Diffusion tensor imaging (DTI) has been proposed to guide the
anisotropic expansion from gross tumor volume to clinical target volume (CTV), aiming to …

Spatial Brain Tumor Concentration Estimation for Individualized Radiotherapy Planning

J Weidner, M Balcerak, I Ezhov, A Datchev… - arXiv preprint arXiv …, 2024 - arxiv.org
Biophysical modeling of brain tumors has emerged as a promising strategy for personalizing
radiotherapy planning by estimating the otherwise hidden distribution of tumor cells within …

A novel approach for radiotherapy treatment planning accounting for high-grade glioma invasiveness into normal tissue

W Häger - 2024 - diva-portal.org
Purpose: High-grade glioma (HGG) is a common form of malignant primary brain cancer
with poor prognosis. The diffusive nature of HGGs implies that tumor cell invasion of normal …

A Novel Approach for Radiotherapy and Radiosurgery Treatment Planning Accounting for High-Grade Glioma Invasiveness into Normal Tissue

W Häger - 2023 - diva-portal.org
High-grade gliomas (HGGs) are a type of malignant brain cancer, which include
glioblastomas (GBMs). In adults, GBM is the most common malignant primary brain cancer …

[PDF][PDF] Exploring the Computational and Clinical Added-value of Probabilistic Optimization in Proton Therapy

E Peeters, R Schyns, JA Lee, E Sterpin - dial.uclouvain.be
The definition of the clinical target volume can be considered as a binary mask. However,
the further a point is from the gross target volume, the less probability it has of being …

[PDF][PDF] Using fluid flow simulations to model microscopic tumor invasion in muscle tissue for radiotherapy treatment

G Buti, A Ajdari, YL Chen, CP Bridge, GC Sharp… - iccr2024.org
A framework is developed to include the preferred path of microscopic tumor invasion along
muscle fibers in radiation target volumes. Following the novel idea that the directionality of …

Multi-modal image confidence: a novel method for tumor and organ boundary representation

L Yang, X Liu, Z Li, Z Li, Z Li, X Yin, XS Qi… - International Journal of …, 2024 - Elsevier
Background The ambiguous boundaries of tumors and organs at risk (OARs) seen in
medical images pose challenges in treatment planning and other tasks in radiotherapy …