Probenecid is an old uricosuric agent used in clinics to treat gout and reduce the renal
excretion of antibiotics. In recent years, probenecid has gained attention due to its ability to …

Considered relevant during allergy responses, numerous observations have also identified
mast cells (MCs) as critical effectors during the progression and modulation of several …

Pannexin1 (Panx1) channels are ubiquitously expressed in vertebrate cells and are widely
accepted as adenosine triphosphate (ATP)-releasing membrane channels. Activation of …

Nicotine in tobacco is known to induce tumor-promoting effects and cause chemotherapy
resistance through the activation of nicotinic acetylcholine receptors (nAChRs). Many …

Muscular dystrophies (MDs) are a heterogeneous group of congenital neuromuscular
disorders whose clinical signs include myalgia, skeletal muscle weakness, hypotonia, and …

Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence
has been reported about the role of this nucleotide and purinergic receptors, in particular …

Background and Purpose ATP is highly accumulated in secretory vesicles and secreted
upon exocytosis from neurons and endocrine cells. In adrenal chromaffin granules …

Inflammation, as a complex immunopathological process, is the organism's natural defense
response against harmful, foreign, and destructive immune or non-immune factors. It is the …

Enhanced activity and overexpression of Pannexin 1 (Panx1) channels contribute to
neuronal pathologies such as epilepsy and Alzheimer's disease (AD). The Panx1 channel …

Protein phosphorylation is one of the major molecular mechanisms regulating protein
activity and function throughout the cell. Pannexin 1 (PANX1) is a large-pore channel …