Genetic architecture of schizophrenia: a review of major advancements

SE Legge, ML Santoro, S Periyasamy… - Psychological …, 2021 - cambridge.org
Schizophrenia is a severe psychiatric disorder with high heritability. Consortia efforts and
technological advancements have led to a substantial increase in knowledge of the genetic …

[HTML][HTML] Systematic review: how the attention-deficit/hyperactivity disorder polygenic risk score adds to our understanding of ADHD and associated traits

A Ronald, N de Bode, TJC Polderman - … of the American Academy of Child …, 2021 - Elsevier
Objective To investigate, by systematically reviewing the literature, whether the attention-
deficit/hyperactivity disorder (ADHD) polygenic risk score (PRS) associates with ADHD and …

A systematic review and narrative synthesis of data-driven studies in schizophrenia symptoms and cognitive deficits

TD Habtewold, LH Rodijk, EJ Liemburg… - Translational …, 2020 - nature.com
To tackle the phenotypic heterogeneity of schizophrenia, data-driven methods are often
applied to identify subtypes of its symptoms and cognitive deficits. However, a systematic …

Associations between schizophrenia polygenic liability, symptom dimensions, and cognitive ability in schizophrenia

SE Legge, AG Cardno, J Allardyce, C Dennison… - JAMA …, 2021 - jamanetwork.com
Importance Schizophrenia is a clinically heterogeneous disorder. It is currently unclear how
variability in symptom dimensions and cognitive ability is associated with genetic liability for …

Subtyping schizophrenia patients based on patterns of structural brain alterations

Y Xiao, W Liao, Z Long, B Tao, Q Zhao… - Schizophrenia …, 2022 - academic.oup.com
Schizophrenia is a complex and heterogeneous syndrome. Whether quantitative imaging
biomarkers can identify discrete subgroups of patients as might be used to foster …

Electrophysiological measures from human iPSC-derived neurons are associated with schizophrenia clinical status and predict individual cognitive performance

SC Page, SR Sripathy, F Farinelli… - Proceedings of the …, 2022 - National Acad Sciences
Neurons derived from human induced pluripotent stem cells (hiPSCs) have been used to
model basic cellular aspects of neuropsychiatric disorders, but the relationship between the …

Insula sub-regions across the psychosis spectrum: morphology and clinical correlates

JM Sheffield, AS Huang, BP Rogers… - Translational …, 2021 - nature.com
The insula is a heterogeneous cortical region, comprised of three cytoarchitecturally distinct
sub-regions (agranular, dysgranular, and granular), which traverse the anterior-posterior …

The genetic architecture of schizophrenia: review of large-scale genetic studies

H Kato, H Kimura, I Kushima, N Takahashi… - Journal of Human …, 2023 - nature.com
Schizophrenia is a complex and often chronic psychiatric disorder with high heritability.
Diagnosis of schizophrenia is still made clinically based on psychiatric symptoms; no …

What do we know about the genetic architecture of psychopathology?

EJ Giangrande, RS Weber… - Annual Review of Clinical …, 2022 - annualreviews.org
In the second half of the twentieth century, twin and family studies established beyond a
reasonable doubt that all forms of psychopathology are substantially heritable and highly …

Early environmental upheaval and the risk for schizophrenia

V Paquin, M Lapierre, F Veru… - Annual Review of Clinical …, 2021 - annualreviews.org
Why does prenatal exposure to wars, natural disasters, urbanicity, or winter increase the risk
for schizophrenia? Research from the last two decades has provided rich insight about the …