The coronavirus disease 2019 (COVID-19) pandemics is a challenge without precedent for
the modern science. Acute Respiratory Discomfort Syndrome (ARDS) is the most common …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

The general view on cysteine cathepsins, which were long believed to be primarily involved
in intracellular protein turnover, has dramatically changed in last 10 to 15 years. The …

Biomedical research often focuses on properties that differentiate between diseased and
healthy tissue; one of the current focuses is elevated expression and altered localisation of …

Macroautophagy serves cellular housekeeping and metabolic functions through delivery of
cytoplasmic constituents for lysosomal degradation. In addition, it may mediate the …

Hybrid insulin peptides (HIPs) form in pancreatic β-cells through the formation of peptide
bonds between proinsulin fragments and other peptides. HIPs have been identified in …

Human cathepsin L belongs to the cathepsin family of proteolytic enzymes with primarily an
endopeptidase activity. Although its primary functions were originally thought to be only of a …

The identification of the peptide epitopes presented by major histocompatibility complex
class II (MHCII) molecules that drive the CD4 T cell component of autoimmune diseases has …

A tetrahydroquinoline oxocarbazate (PubChem CID 23631927) was tested as an inhibitor of
human cathepsin L (EC 3.4. 22.15) and as an entry blocker of severe acute respiratory …

Type 1 diabetes is an insulin-dependent, autoimmune disease where the pancreatic β cells
are destroyed resulting in hyperglycemia. This multifactorial disease involves multiple …