Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Virus–receptor interactions play a key regulatory role in viral host range, tissue tropism, and
viral pathogenesis. Viruses utilize elegant strategies to attach to one or multiple receptors …

Oligodendrocytes produce myelin, an insulating sheath required for the saltatory conduction
of electrical impulses along axons. Oligodendrocyte loss results in demyelination, which …

Animal models play a pivotal role in translational neuroscience but recurrent problems in
data collection, analyses, and interpretation, lack of biomarkers, and a tendency to over …

Many neurological diseases of the central nervous system (CNS) are underpinned by
malfunctions of the immune system, including disorders involving opportunistic infections …

In the fifty years since the discovery of JC polyomavirus (JCPyV), the body of research
representing our collective knowledge on this virus has grown substantially. As the …

JC polyomavirus (JCPyV) is the causative agent of a fatal central nervous system
demyelinating disease known as progressive multifocal leukoencephalopathy (PML). PML …

BK polyomavirus (BKV) frequently causes nephropathy (BKVN) in kidney transplant
recipients (KTRs). BKV has also been implicated in the etiology of bladder and kidney …

Model animals naturally differ from humans in various respects and results from the former
are not directly translatable to the latter. One approach to address this issue is humanized …

Progress in stem cell research has revolutionized the medical field for more than two
decades. More recently, the discovery of induced pluripotent stem cells (iPSCs) has allowed …