The diabetes mellitus–atherosclerosis connection: The role of lipid and glucose metabolism and chronic inflammation
Diabetes mellitus comprises a group of carbohydrate metabolism disorders that share a
common main feature of chronic hyperglycemia that results from defects of insulin secretion …
common main feature of chronic hyperglycemia that results from defects of insulin secretion …
[HTML][HTML] New insights into oxidative stress and inflammation during diabetes mellitus-accelerated atherosclerosis
Oxidative stress and inflammation interact in the development of diabetic atherosclerosis.
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …
Intracellular hyperglycemia promotes production of mitochondrial reactive oxygen species …
Kinase-targeted cancer therapies: progress, challenges and future directions
KS Bhullar, NO Lagarón, EM McGowan, I Parmar… - Molecular cancer, 2018 - Springer
The human genome encodes 538 protein kinases that transfer a γ-phosphate group from
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
ATP to serine, threonine, or tyrosine residues. Many of these kinases are associated with …
Endothelial dysfunction and vascular disease–a 30th anniversary update
PM Vanhoutte, H Shimokawa, M Feletou… - Acta …, 2017 - Wiley Online Library
The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …
Insulin resistance the hinge between hypertension and type 2 diabetes
Epidemiological studies have documented a high incidence of diabetes in hypertensive
patients. Insulin resistance is defined as a less than expected biologic response to a given …
patients. Insulin resistance is defined as a less than expected biologic response to a given …
Molecular and cellular mechanisms of cardiovascular disorders in diabetes
MS Shah, M Brownlee - Circulation research, 2016 - Am Heart Assoc
The clinical correlations linking diabetes mellitus with accelerated atherosclerosis,
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
cardiomyopathy, and increased post-myocardial infarction fatality rates are increasingly …
Ageing, metabolism and cardiovascular disease
S Costantino, F Paneni… - The Journal of physiology, 2016 - Wiley Online Library
Age is one of the major risk factors associated with cardiovascular disease (CVD). About
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …
one‐fifth of the world population will be aged 65 or older by 2030, with an exponential …
The role of oxidative stress in diabetes mellitus-induced vascular endothelial dysfunction
Y An, B Xu, S Wan, X Ma, Y Long, Y Xu… - Cardiovascular …, 2023 - Springer
Diabetes mellitus is a metabolic disease characterized by long-term hyperglycaemia, which
leads to microangiopathy and macroangiopathy and ultimately increases the mortality of …
leads to microangiopathy and macroangiopathy and ultimately increases the mortality of …
PTMD: a database of human disease-associated post-translational modifications
Various posttranslational modifications (PTMs) participate in nearly all aspects of biological
processes by regulating protein functions, and aberrant states of PTMs are frequently …
processes by regulating protein functions, and aberrant states of PTMs are frequently …
Clinical characteristics and outcomes among hospitalized adults with severe COVID-19 admitted to a tertiary medical center and receiving antiviral, antimalarials …
P Guisado-Vasco, S Valderas-Ortega… - …, 2020 - thelancet.com
Background The COVID-19 outbreak challenges the Spanish health system since March
2020. Some available therapies (antimalarials, antivirals, biological agents) were grounded …
2020. Some available therapies (antimalarials, antivirals, biological agents) were grounded …