The first matrix metalloproteinase (MMP) was discovered in 1962 from the tail of a tadpole by
its ability to degrade collagen. As their name suggests, matrix metalloproteinases are …

As a complex multicellular structure of the vascular system at the central nervous system
(CNS), the blood-brain barrier (BBB) separates the CNS from the system circulation and …

Sepsis is a life-threatening clinical condition caused by a dysregulated host response to
infection. Sepsis-associated encephalopathy (SAE) is a common but poorly understood …

Introduction Sepsis-associated encephalopathy (SAE) and septic encephalitis (SE) are
associated with increased mortality, long-term cognitive impairment, and focal neurological …

Sepsis is a major cause of death in intensive care units worldwide. The acute phase of
sepsis is often accompanied by sepsis-associated encephalopathy, which is highly …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. Sepsis causes cerebral dysfunction in the short and long term and induces …

Dysregulated host response to infection, which cause life‐threatening organ dysfunction,
was defined as sepsis. Sepsis can cause acute and long‐term brain dysfunction, namely …

Sepsis-associated cerebral dysfunction is complex pathophysiology, generated from primary
infections that are developed elsewhere in the body. The neonates, elderly population and …

Background Out of the myriad of complications associated with septic shock, septic-
associated encephalopathy (SAE) carries a significant risk of morbidity and mortality. Blood …

Sepsis is an organ dysfunction caused by an uncontrolled inflammatory response from the
host to an infection. Sepsis is the main cause of morbidity and mortality in intensive care …